Cadmium Impairs Albumin Reabsorption by Down-regulating Megalin and ClC5 Channels in Renal Proximal Tubule Cells

BACKGROUND: Cadmium (Cd) is a potent nephrotoxicant that impairs the reabsorptive and secretory functions of the renal proximal tubule, leading to albuminuria. OBJECTIVES: To gain insights into the mechanisms of Cd-induced albuminuria, we investigated effects of Cd on the expression of megalin and c...

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Detalles Bibliográficos
Autores principales: Gena, Patrizia, Calamita, Giuseppe, Guggino, William B.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974692/
https://www.ncbi.nlm.nih.gov/pubmed/20576581
http://dx.doi.org/10.1289/ehp.0901874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974692/
https://www.ncbi.nlm.nih.gov/pubmed/20576581
http://dx.doi.org/10.1289/ehp.0901874

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