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Cadmium Impairs Albumin Reabsorption by Down-regulating Megalin and ClC5 Channels in Renal Proximal Tubule Cells
BACKGROUND: Cadmium (Cd) is a potent nephrotoxicant that impairs the reabsorptive and secretory functions of the renal proximal tubule, leading to albuminuria. OBJECTIVES: To gain insights into the mechanisms of Cd-induced albuminuria, we investigated effects of Cd on the expression of megalin and c...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
National Institute of Environmental Health Sciences
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974692/ https://www.ncbi.nlm.nih.gov/pubmed/20576581 http://dx.doi.org/10.1289/ehp.0901874 |