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Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study
BACKGROUND: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. OBJECTIVE: We investigated whether ambient black carbon (BC), a marker for traffic-re...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974694/ https://www.ncbi.nlm.nih.gov/pubmed/21465749 http://dx.doi.org/10.1289/ehp.0901831 |
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author | McCracken, John Baccarelli, Andrea Hoxha, Mirjam Dioni, Laura Melly, Steve Coull, Brent Suh, Helen Vokonas, Pantel Schwartz, Joel |
author_facet | McCracken, John Baccarelli, Andrea Hoxha, Mirjam Dioni, Laura Melly, Steve Coull, Brent Suh, Helen Vokonas, Pantel Schwartz, Joel |
author_sort | McCracken, John |
collection | PubMed |
description | BACKGROUND: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. OBJECTIVE: We investigated whether ambient black carbon (BC), a marker for traffic-related particles, is associated with telomere length in the Normative Aging Study (NAS). METHODS: Among 165 never-smoking men from the NAS, leukocyte telomere length (LTL) was measured repeatedly approximately every 3 years from 1999 through 2006 using quantitative real-time polymerase chain reaction (qRT-PCR). BC concentration at their residences during the year before each LTL measurement was estimated based on a spatiotemporal model calibrated with BC measurements from 82 locations within the study area. RESULTS: The median [interquartile range (IQR)] annual moving-average BC concentration was 0.32 (0.20–0.45) μg/m(3). LTL, expressed as population-standardized ratio of telomere repeat to single-copy gene copy numbers, had a geometric mean (geometric SD) of 1.25 (1.42). We used linear mixed-effects models including random subject intercepts and adjusted for several potential confounders. We used inverse probability of response weighting to adjust for potential selection bias due to loss to follow-up. An IQR increase in annual BC (0.25 μg/m(3)) was associated with a 7.6% decrease (95% confidence interval, −12.8 to −2.1) in LTL. We found evidence of effect modification, with a stronger association among subjects ≥ 75 years of age compared with younger participants (p = 0.050) and statin medications appearing protective of the effects of BC on LTL (p = 0.050). CONCLUSIONS: Telomere attrition, linked to biological aging, may be associated with long-term exposures to airborne particles, particularly those rich in BC, which are primarily related to automobile traffic. |
format | Text |
id | pubmed-2974694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-29746942010-11-22 Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study McCracken, John Baccarelli, Andrea Hoxha, Mirjam Dioni, Laura Melly, Steve Coull, Brent Suh, Helen Vokonas, Pantel Schwartz, Joel Environ Health Perspect Research BACKGROUND: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. OBJECTIVE: We investigated whether ambient black carbon (BC), a marker for traffic-related particles, is associated with telomere length in the Normative Aging Study (NAS). METHODS: Among 165 never-smoking men from the NAS, leukocyte telomere length (LTL) was measured repeatedly approximately every 3 years from 1999 through 2006 using quantitative real-time polymerase chain reaction (qRT-PCR). BC concentration at their residences during the year before each LTL measurement was estimated based on a spatiotemporal model calibrated with BC measurements from 82 locations within the study area. RESULTS: The median [interquartile range (IQR)] annual moving-average BC concentration was 0.32 (0.20–0.45) μg/m(3). LTL, expressed as population-standardized ratio of telomere repeat to single-copy gene copy numbers, had a geometric mean (geometric SD) of 1.25 (1.42). We used linear mixed-effects models including random subject intercepts and adjusted for several potential confounders. We used inverse probability of response weighting to adjust for potential selection bias due to loss to follow-up. An IQR increase in annual BC (0.25 μg/m(3)) was associated with a 7.6% decrease (95% confidence interval, −12.8 to −2.1) in LTL. We found evidence of effect modification, with a stronger association among subjects ≥ 75 years of age compared with younger participants (p = 0.050) and statin medications appearing protective of the effects of BC on LTL (p = 0.050). CONCLUSIONS: Telomere attrition, linked to biological aging, may be associated with long-term exposures to airborne particles, particularly those rich in BC, which are primarily related to automobile traffic. National Institute of Environmental Health Sciences 2010-11 2010-08-17 /pmc/articles/PMC2974694/ /pubmed/21465749 http://dx.doi.org/10.1289/ehp.0901831 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research McCracken, John Baccarelli, Andrea Hoxha, Mirjam Dioni, Laura Melly, Steve Coull, Brent Suh, Helen Vokonas, Pantel Schwartz, Joel Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study |
title | Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study |
title_full | Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study |
title_fullStr | Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study |
title_full_unstemmed | Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study |
title_short | Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study |
title_sort | annual ambient black carbon associated with shorter telomeres in elderly men: veterans affairs normative aging study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974694/ https://www.ncbi.nlm.nih.gov/pubmed/21465749 http://dx.doi.org/10.1289/ehp.0901831 |
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