Amyloid-binding Small Molecules Efficiently Block SEVI (Semen-derived Enhancer of Virus Infection)- and Semen-mediated Enhancement of HIV-1 Infection

Semen was recently shown to contain amyloid fibrils formed from a self-assembling peptide fragment of the protein prostatic acid phosphatase. These amyloid fibrils, termed semen-derived enhancer of virus infection, or SEVI, have been shown to strongly enhance HIV infectivity and may play an importan...

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Detalles Bibliográficos
Autores principales: Olsen, Joanna S., Brown, Caitlin, Capule, Christina C., Rubinshtein, Mark, Doran, Todd M., Srivastava, Rajesh K., Feng, Changyong, Nilsson, Bradley L., Yang, Jerry, Dewhurst, Stephen
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975173/
https://www.ncbi.nlm.nih.gov/pubmed/20833717
http://dx.doi.org/10.1074/jbc.M110.163659

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