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Molecular imaging in atherosclerosis

Atherosclerosis is the major cause of cardiovascular disease, which still has the leading position in morbidity and mortality in the Western world. Many risk factors and pathobiological processes are acting together in the development of atherosclerosis. This leads to different remodelling stages (p...

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Autores principales: Glaudemans, Andor W. J. M., Slart, Riemer H. J. A., Bozzao, Alessandro, Bonanno, Elena, Arca, Marcello, Dierckx, Rudi A. J. O., Signore, Alberto
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975909/
https://www.ncbi.nlm.nih.gov/pubmed/20306036
http://dx.doi.org/10.1007/s00259-010-1406-4
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author Glaudemans, Andor W. J. M.
Slart, Riemer H. J. A.
Bozzao, Alessandro
Bonanno, Elena
Arca, Marcello
Dierckx, Rudi A. J. O.
Signore, Alberto
author_facet Glaudemans, Andor W. J. M.
Slart, Riemer H. J. A.
Bozzao, Alessandro
Bonanno, Elena
Arca, Marcello
Dierckx, Rudi A. J. O.
Signore, Alberto
author_sort Glaudemans, Andor W. J. M.
collection PubMed
description Atherosclerosis is the major cause of cardiovascular disease, which still has the leading position in morbidity and mortality in the Western world. Many risk factors and pathobiological processes are acting together in the development of atherosclerosis. This leads to different remodelling stages (positive and negative) which are both associated with plaque physiology and clinical presentation. The different remodelling stages of atherosclerosis are explained with their clinical relevance. Recent advances in basic science have established that atherosclerosis is not only a lipid storage disease, but that also inflammation has a fundamental role in all stages of the disease. The molecular events leading to atherosclerosis will be extensively reviewed and described. Further on in this review different modalities and their role in the different stages of atherosclerosis will be discussed. Non-nuclear invasive imaging techniques (intravascular ultrasound, intravascular MRI, intracoronary angioscopy and intravascular optical coherence tomography) and non-nuclear non-invasive imaging techniques (ultrasound with Doppler flow, electron-bean computed tomography, coronary computed tomography angiography, MRI and coronary artery MR angiography) will be reviewed. After that we focus on nuclear imaging techniques for detecting atherosclerotic plaques, divided into three groups: atherosclerotic lesion components, inflammation and thrombosis. This emerging area of nuclear imaging techniques can provide measures of biological activity of atherosclerotic plaques, thereby improving the prediction of clinical events. As we will see in the future perspectives, at present, there is no special tracer that can be called the diagnostic tool to diagnose prospective stroke or infarction in patients. Nevertheless, we expect such a tracer to be developed in the next few years and maybe, theoretically, it could even be used for targeted therapy (in the form of a beta-emitter) to combat cardiovascular disease.
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spelling pubmed-29759092010-11-29 Molecular imaging in atherosclerosis Glaudemans, Andor W. J. M. Slart, Riemer H. J. A. Bozzao, Alessandro Bonanno, Elena Arca, Marcello Dierckx, Rudi A. J. O. Signore, Alberto Eur J Nucl Med Mol Imaging Review Article Atherosclerosis is the major cause of cardiovascular disease, which still has the leading position in morbidity and mortality in the Western world. Many risk factors and pathobiological processes are acting together in the development of atherosclerosis. This leads to different remodelling stages (positive and negative) which are both associated with plaque physiology and clinical presentation. The different remodelling stages of atherosclerosis are explained with their clinical relevance. Recent advances in basic science have established that atherosclerosis is not only a lipid storage disease, but that also inflammation has a fundamental role in all stages of the disease. The molecular events leading to atherosclerosis will be extensively reviewed and described. Further on in this review different modalities and their role in the different stages of atherosclerosis will be discussed. Non-nuclear invasive imaging techniques (intravascular ultrasound, intravascular MRI, intracoronary angioscopy and intravascular optical coherence tomography) and non-nuclear non-invasive imaging techniques (ultrasound with Doppler flow, electron-bean computed tomography, coronary computed tomography angiography, MRI and coronary artery MR angiography) will be reviewed. After that we focus on nuclear imaging techniques for detecting atherosclerotic plaques, divided into three groups: atherosclerotic lesion components, inflammation and thrombosis. This emerging area of nuclear imaging techniques can provide measures of biological activity of atherosclerotic plaques, thereby improving the prediction of clinical events. As we will see in the future perspectives, at present, there is no special tracer that can be called the diagnostic tool to diagnose prospective stroke or infarction in patients. Nevertheless, we expect such a tracer to be developed in the next few years and maybe, theoretically, it could even be used for targeted therapy (in the form of a beta-emitter) to combat cardiovascular disease. Springer-Verlag 2010-03-20 2010 /pmc/articles/PMC2975909/ /pubmed/20306036 http://dx.doi.org/10.1007/s00259-010-1406-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review Article
Glaudemans, Andor W. J. M.
Slart, Riemer H. J. A.
Bozzao, Alessandro
Bonanno, Elena
Arca, Marcello
Dierckx, Rudi A. J. O.
Signore, Alberto
Molecular imaging in atherosclerosis
title Molecular imaging in atherosclerosis
title_full Molecular imaging in atherosclerosis
title_fullStr Molecular imaging in atherosclerosis
title_full_unstemmed Molecular imaging in atherosclerosis
title_short Molecular imaging in atherosclerosis
title_sort molecular imaging in atherosclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975909/
https://www.ncbi.nlm.nih.gov/pubmed/20306036
http://dx.doi.org/10.1007/s00259-010-1406-4
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