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Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and...

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Detalles Bibliográficos
Autores principales: Monroe, Marcus M., Anderson, Eric C., Clayburgh, Daniel R., Wong, Melissa H.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976506/
https://www.ncbi.nlm.nih.gov/pubmed/21076545
http://dx.doi.org/10.1155/2011/762780
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author Monroe, Marcus M.
Anderson, Eric C.
Clayburgh, Daniel R.
Wong, Melissa H.
author_facet Monroe, Marcus M.
Anderson, Eric C.
Clayburgh, Daniel R.
Wong, Melissa H.
author_sort Monroe, Marcus M.
collection PubMed
description Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and neck squamous cell carcinoma (HNSCC), as with other malignancies, cancer stem cells have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In this paper we summarize the current knowledge of the role of CSCs in HNSCC and discuss the therapeutic implications and future directions of this field.
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spelling pubmed-29765062010-11-12 Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma Monroe, Marcus M. Anderson, Eric C. Clayburgh, Daniel R. Wong, Melissa H. J Oncol Review Article Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and neck squamous cell carcinoma (HNSCC), as with other malignancies, cancer stem cells have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In this paper we summarize the current knowledge of the role of CSCs in HNSCC and discuss the therapeutic implications and future directions of this field. Hindawi Publishing Corporation 2011 2010-11-08 /pmc/articles/PMC2976506/ /pubmed/21076545 http://dx.doi.org/10.1155/2011/762780 Text en Copyright © 2011 Marcus M. Monroe et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Monroe, Marcus M.
Anderson, Eric C.
Clayburgh, Daniel R.
Wong, Melissa H.
Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma
title Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma
title_full Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma
title_fullStr Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma
title_short Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma
title_sort cancer stem cells in head and neck squamous cell carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976506/
https://www.ncbi.nlm.nih.gov/pubmed/21076545
http://dx.doi.org/10.1155/2011/762780
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