Suppression of Hypoxia-Inducible Factor 1α (HIF-1α) by Tirapazamine Is Dependent on eIF2α Phosphorylation Rather Than the mTORC1/4E-BP1 Pathway

Hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that mediates the adaptation of tumor cells and tissues to the hypoxic microenvironment, has attracted considerable interest as a potential therapeutic target. Tirapazamine (TPZ), a well-characterized bioreductive anticancer ag...

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Detalles Bibliográficos
Autores principales: Zhang, Jun, Cao, Ji, Weng, Qinjie, Wu, Rui, Yan, Yan, Jing, Hui, Zhu, Hong, He, Qiaojun, Yang, Bo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976688/
https://www.ncbi.nlm.nih.gov/pubmed/21085474
http://dx.doi.org/10.1371/journal.pone.0013910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976688/
https://www.ncbi.nlm.nih.gov/pubmed/21085474
http://dx.doi.org/10.1371/journal.pone.0013910

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