Interaction of the Retinoblastoma Protein with Orc1 and Its Recruitment to Human Origins of DNA Replication

BACKGROUND: The retinoblastoma protein (Rb) is a crucial regulator of cell cycle progression by binding with E2F transcription factor and repressing the expression of a variety of genes required for the G1-S phase transition. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that Rb and E2F1 directly par...

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Detalles Bibliográficos
Autores principales: Mendoza-Maldonado, Ramiro, Paolinelli, Roberta, Galbiati, Laura, Giadrossi, Sara, Giacca, Mauro
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976706/
https://www.ncbi.nlm.nih.gov/pubmed/21085491
http://dx.doi.org/10.1371/journal.pone.0013720

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