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1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one
In the title compound C(19)H(16)ClF(2)NO(2), the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C⋯O intermolecular contacts are observed in...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977122/ https://www.ncbi.nlm.nih.gov/pubmed/21583667 http://dx.doi.org/10.1107/S1600536809028529 |
Sumario: | In the title compound C(19)H(16)ClF(2)NO(2), the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C⋯O intermolecular contacts are observed in the structure, within a 3.00 Å range. The crystal packing is stabilized by C—H⋯O and C—H⋯F hydrogen bonds and an intermolecular π–π interaction [centroid-centroid separation of 3.783 (1) Å]. Alternating C—H⋯O and C—H⋯F intermolecular interactions generate chains running along the a axis, while a centrosymmetric R (2) (2)(16) ring involving C—H⋯O interactions is formed centred at (1/2, 1/2, 0). |
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