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1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one
In the title compound C(19)H(16)ClF(2)NO(2), the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C⋯O intermolecular contacts are observed in...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977122/ https://www.ncbi.nlm.nih.gov/pubmed/21583667 http://dx.doi.org/10.1107/S1600536809028529 |
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author | Aridoss, G. Gayathri, D. Velmurugan, D. Kim, M. S. Jeong, Yeon Tae |
author_facet | Aridoss, G. Gayathri, D. Velmurugan, D. Kim, M. S. Jeong, Yeon Tae |
author_sort | Aridoss, G. |
collection | PubMed |
description | In the title compound C(19)H(16)ClF(2)NO(2), the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C⋯O intermolecular contacts are observed in the structure, within a 3.00 Å range. The crystal packing is stabilized by C—H⋯O and C—H⋯F hydrogen bonds and an intermolecular π–π interaction [centroid-centroid separation of 3.783 (1) Å]. Alternating C—H⋯O and C—H⋯F intermolecular interactions generate chains running along the a axis, while a centrosymmetric R (2) (2)(16) ring involving C—H⋯O interactions is formed centred at (1/2, 1/2, 0). |
format | Text |
id | pubmed-2977122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-29771222010-12-30 1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one Aridoss, G. Gayathri, D. Velmurugan, D. Kim, M. S. Jeong, Yeon Tae Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound C(19)H(16)ClF(2)NO(2), the piperidone ring adopts a twist-boat conformation with the two out-of-plane atoms deviating by 0.544 (1) and 0.511 (1) Å from the plane through the remaining atoms in the ring. Sterically favoured non-H-atom C⋯O intermolecular contacts are observed in the structure, within a 3.00 Å range. The crystal packing is stabilized by C—H⋯O and C—H⋯F hydrogen bonds and an intermolecular π–π interaction [centroid-centroid separation of 3.783 (1) Å]. Alternating C—H⋯O and C—H⋯F intermolecular interactions generate chains running along the a axis, while a centrosymmetric R (2) (2)(16) ring involving C—H⋯O interactions is formed centred at (1/2, 1/2, 0). International Union of Crystallography 2009-07-25 /pmc/articles/PMC2977122/ /pubmed/21583667 http://dx.doi.org/10.1107/S1600536809028529 Text en © Aridoss et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Aridoss, G. Gayathri, D. Velmurugan, D. Kim, M. S. Jeong, Yeon Tae 1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one |
title | 1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one |
title_full | 1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one |
title_fullStr | 1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one |
title_full_unstemmed | 1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one |
title_short | 1-Chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one |
title_sort | 1-chloroacetyl-2,6-bis(3-fluorophenyl)piperidin-4-one |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977122/ https://www.ncbi.nlm.nih.gov/pubmed/21583667 http://dx.doi.org/10.1107/S1600536809028529 |
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