Carvedilol dihydrogen phosphate hemihydrate: a powder study

In the cation of the title compound [systematic name: 3-(9H-carbazol-4-yl­oxy)-2-hydr­oxy-N-[2-(2-methoxy­phen­oxy)eth­yl]propan-1-aminium dihydrogen phosphate hemihydrate], C(24)H(27)N(2)O(4) (+)·H(2)PO(4) (−)·0.5H(2)O, the mean planes of the tricyclic ring system and the benzene ring form a dihedr...

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Detalles Bibliográficos
Autores principales: Chernyshev, Vladimir V., Machula, Alexandre A., Kukushkin, Sergei Yu., Velikodny, Yurii A.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977435/
https://www.ncbi.nlm.nih.gov/pubmed/21583690
http://dx.doi.org/10.1107/S1600536809029353
Descripción
Sumario:In the cation of the title compound [systematic name: 3-(9H-carbazol-4-yl­oxy)-2-hydr­oxy-N-[2-(2-methoxy­phen­oxy)eth­yl]propan-1-aminium dihydrogen phosphate hemihydrate], C(24)H(27)N(2)O(4) (+)·H(2)PO(4) (−)·0.5H(2)O, the mean planes of the tricyclic ring system and the benzene ring form a dihedral angle of 87.2 (2)°. In the crystal structure, the solvent water mol­ecule is situated on a twofold rotation axis linking two cations via O—H⋯O and N—H⋯O hydrogen bonds. The anions contribute to the formation O—H⋯O and N—H⋯O hydrogen bonds between the anions and cations, which consolidate the crystal packing.

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