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Ethyl 4-(2,4-difluoro­phen­yl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetra­hydro­pyrimidine-5-carboxyl­ate

The asymmetric unit of the title compound, C(20)H(18)F(2)N(2)O(2)S, contains four independent mol­ecules, two of which are paired into a dimer by way of two N—H⋯S hydrogen bonds. The other two independent mol­ecules are paired into two centrosymmetric dimers via pairs of inter­molecular N—H⋯S hydrog...

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Detalles Bibliográficos
Autores principales: Fun, Hoong-Kun, Jebas, Samuel Robinson, Babu, M., Kalluraya, B.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977677/
https://www.ncbi.nlm.nih.gov/pubmed/21584020
http://dx.doi.org/10.1107/S160053680901232X
Descripción
Sumario:The asymmetric unit of the title compound, C(20)H(18)F(2)N(2)O(2)S, contains four independent mol­ecules, two of which are paired into a dimer by way of two N—H⋯S hydrogen bonds. The other two independent mol­ecules are paired into two centrosymmetric dimers via pairs of inter­molecular N—H⋯S hydrogen bonds. In one mol­ecule, the carboxyl­ate O atoms, methyl­ene and methyl groups attached to the benzene ring are disordered between two positions in a 0.908 (3):0.092 (3) ratio. In two of the independent mol­ecules, the F and H atoms of the diflourophenyl ring are flip-flop disordered (i.e. by 180° about the C—C bond axis linking the ring to the rest of the molecule) in a 3:2 ratio. The crystal packing is stabilized by weak inter­molecular C—H⋯O hydrogen bonds.