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Ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
The asymmetric unit of the title compound, C(20)H(18)F(2)N(2)O(2)S, contains four independent molecules, two of which are paired into a dimer by way of two N—H⋯S hydrogen bonds. The other two independent molecules are paired into two centrosymmetric dimers via pairs of intermolecular N—H⋯S hydrog...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977677/ https://www.ncbi.nlm.nih.gov/pubmed/21584020 http://dx.doi.org/10.1107/S160053680901232X |
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author | Fun, Hoong-Kun Jebas, Samuel Robinson Babu, M. Kalluraya, B. |
author_facet | Fun, Hoong-Kun Jebas, Samuel Robinson Babu, M. Kalluraya, B. |
author_sort | Fun, Hoong-Kun |
collection | PubMed |
description | The asymmetric unit of the title compound, C(20)H(18)F(2)N(2)O(2)S, contains four independent molecules, two of which are paired into a dimer by way of two N—H⋯S hydrogen bonds. The other two independent molecules are paired into two centrosymmetric dimers via pairs of intermolecular N—H⋯S hydrogen bonds. In one molecule, the carboxylate O atoms, methylene and methyl groups attached to the benzene ring are disordered between two positions in a 0.908 (3):0.092 (3) ratio. In two of the independent molecules, the F and H atoms of the diflourophenyl ring are flip-flop disordered (i.e. by 180° about the C—C bond axis linking the ring to the rest of the molecule) in a 3:2 ratio. The crystal packing is stabilized by weak intermolecular C—H⋯O hydrogen bonds. |
format | Text |
id | pubmed-2977677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-29776772010-12-30 Ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate Fun, Hoong-Kun Jebas, Samuel Robinson Babu, M. Kalluraya, B. Acta Crystallogr Sect E Struct Rep Online Organic Papers The asymmetric unit of the title compound, C(20)H(18)F(2)N(2)O(2)S, contains four independent molecules, two of which are paired into a dimer by way of two N—H⋯S hydrogen bonds. The other two independent molecules are paired into two centrosymmetric dimers via pairs of intermolecular N—H⋯S hydrogen bonds. In one molecule, the carboxylate O atoms, methylene and methyl groups attached to the benzene ring are disordered between two positions in a 0.908 (3):0.092 (3) ratio. In two of the independent molecules, the F and H atoms of the diflourophenyl ring are flip-flop disordered (i.e. by 180° about the C—C bond axis linking the ring to the rest of the molecule) in a 3:2 ratio. The crystal packing is stabilized by weak intermolecular C—H⋯O hydrogen bonds. International Union of Crystallography 2009-04-08 /pmc/articles/PMC2977677/ /pubmed/21584020 http://dx.doi.org/10.1107/S160053680901232X Text en © Fun et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Fun, Hoong-Kun Jebas, Samuel Robinson Babu, M. Kalluraya, B. Ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
title | Ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
title_full | Ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
title_fullStr | Ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
title_full_unstemmed | Ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
title_short | Ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
title_sort | ethyl 4-(2,4-difluorophenyl)-6-methyl-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977677/ https://www.ncbi.nlm.nih.gov/pubmed/21584020 http://dx.doi.org/10.1107/S160053680901232X |
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