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Racemic N-methyl-4-[2-(methyl­sulfan­yl)­pyrimidin-4-yl]-1-(tetra­hydro­furan-3-yl)-1H-pyrazol-5-amine

The title compound, C(13)H(17)N(5)OS, was obtained by cyclo­addition of 2-[2-(methyl­sulfan­yl)pyrimidin-4-yl]-3-oxo­propane­nitrile with (tetra­hydro­furan-3-yl)hydrazine dihydro­chloride and subsequent N-methyl­ation of 4-[2-(methyl­sulfan­yl)­pyrimidin-4-yl]-1-(tetra­hydro­furan-2-yl)-1H-pyrazol-...

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Detalles Bibliográficos
Autores principales: Liu, Zhengyu, Liu, Kevin K.-C., Rheingold, Arnold L., DiPasquale, Antonio, Yanovsky, Alex
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977768/
https://www.ncbi.nlm.nih.gov/pubmed/21583904
http://dx.doi.org/10.1107/S1600536809014317
Descripción
Sumario:The title compound, C(13)H(17)N(5)OS, was obtained by cyclo­addition of 2-[2-(methyl­sulfan­yl)pyrimidin-4-yl]-3-oxo­propane­nitrile with (tetra­hydro­furan-3-yl)hydrazine dihydro­chloride and subsequent N-methyl­ation of 4-[2-(methyl­sulfan­yl)­pyrimidin-4-yl]-1-(tetra­hydro­furan-2-yl)-1H-pyrazol-5-amine with methyl iodide. The two mol­ecules in the asymmetric unit have opposite absolute configurations and are related by a noncrystallographic inversion center. Both feature intra­mol­ecular N—H⋯N hydrogen bonds. The geometry of the mol­ecules is similar to that observed in the structure of a single enanti­omer of the title compound.