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Racemic N-methyl-4-[2-(methylsulfanyl)pyrimidin-4-yl]-1-(tetrahydrofuran-3-yl)-1H-pyrazol-5-amine
The title compound, C(13)H(17)N(5)OS, was obtained by cycloaddition of 2-[2-(methylsulfanyl)pyrimidin-4-yl]-3-oxopropanenitrile with (tetrahydrofuran-3-yl)hydrazine dihydrochloride and subsequent N-methylation of 4-[2-(methylsulfanyl)pyrimidin-4-yl]-1-(tetrahydrofuran-2-yl)-1H-pyrazol-...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977768/ https://www.ncbi.nlm.nih.gov/pubmed/21583904 http://dx.doi.org/10.1107/S1600536809014317 |
Sumario: | The title compound, C(13)H(17)N(5)OS, was obtained by cycloaddition of 2-[2-(methylsulfanyl)pyrimidin-4-yl]-3-oxopropanenitrile with (tetrahydrofuran-3-yl)hydrazine dihydrochloride and subsequent N-methylation of 4-[2-(methylsulfanyl)pyrimidin-4-yl]-1-(tetrahydrofuran-2-yl)-1H-pyrazol-5-amine with methyl iodide. The two molecules in the asymmetric unit have opposite absolute configurations and are related by a noncrystallographic inversion center. Both feature intramolecular N—H⋯N hydrogen bonds. The geometry of the molecules is similar to that observed in the structure of a single enantiomer of the title compound. |
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