6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one

The title compound, C(14)H(18)N(2)O, was synthesized by the reaction of cyclo­hexa­none and 2-amino-5-methyl­benzonitrile. In the mol­ecule, the cyclo­hexane ring displays a chair conformation, whereas the 1,3-diaza­cyclo­hexane moiety of the bicyclic system has a sofa conformation with the spiro C...

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Detalles Bibliográficos
Autores principales: Ling, Zhang, Shi, Daxin, Yanqiu, Fan, Wei, Xia, Li, Jiarong
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977775/
https://www.ncbi.nlm.nih.gov/pubmed/21583911
http://dx.doi.org/10.1107/S1600536809014111
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author Ling, Zhang
Shi, Daxin
Yanqiu, Fan
Wei, Xia
Li, Jiarong
author_facet Ling, Zhang
Shi, Daxin
Yanqiu, Fan
Wei, Xia
Li, Jiarong
author_sort Ling, Zhang
collection PubMed
description The title compound, C(14)H(18)N(2)O, was synthesized by the reaction of cyclo­hexa­none and 2-amino-5-methyl­benzonitrile. In the mol­ecule, the cyclo­hexane ring displays a chair conformation, whereas the 1,3-diaza­cyclo­hexane moiety of the bicyclic system has a sofa conformation with the spiro C atom displaced by 0.603 (2) Å from the rest of the atoms of the 1,3-diaza­cyclo­hexane ring [planar within 0.052 (2) Å]. Mol­ecules are linked into centrosymmetric dimers via N—H⋯O hydrogen bonds.
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spelling pubmed-29777752010-12-30 6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one Ling, Zhang Shi, Daxin Yanqiu, Fan Wei, Xia Li, Jiarong Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(14)H(18)N(2)O, was synthesized by the reaction of cyclo­hexa­none and 2-amino-5-methyl­benzonitrile. In the mol­ecule, the cyclo­hexane ring displays a chair conformation, whereas the 1,3-diaza­cyclo­hexane moiety of the bicyclic system has a sofa conformation with the spiro C atom displaced by 0.603 (2) Å from the rest of the atoms of the 1,3-diaza­cyclo­hexane ring [planar within 0.052 (2) Å]. Mol­ecules are linked into centrosymmetric dimers via N—H⋯O hydrogen bonds. International Union of Crystallography 2009-04-22 /pmc/articles/PMC2977775/ /pubmed/21583911 http://dx.doi.org/10.1107/S1600536809014111 Text en © Ling et al. 2009 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Ling, Zhang
Shi, Daxin
Yanqiu, Fan
Wei, Xia
Li, Jiarong
6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one
title 6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one
title_full 6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one
title_fullStr 6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one
title_full_unstemmed 6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one
title_short 6′-Methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one
title_sort 6′-methyl-1′,2′,3′,4′-tetra­hydro­spiro­cyclo­hexane-2′-quinazolin-4′-one
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977775/
https://www.ncbi.nlm.nih.gov/pubmed/21583911
http://dx.doi.org/10.1107/S1600536809014111
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