The trafficking of Na(V)1.8

The α-subunit of tetrodotoxin-resistant voltage-gated sodium channel Na(V)1.8 is selectively expressed in sensory neurons. It has been reported that Na(V)1.8 is involved in the transmission of nociceptive information from sensory neurons to the central nervous system in nociceptive [1] and neuropath...

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Detalles Bibliográficos
Autores principales: Swanwick, Richard S., Pristerá, Alessandro, Okuse, Kenji
Formato: Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers Ireland 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977848/
https://www.ncbi.nlm.nih.gov/pubmed/20816723
http://dx.doi.org/10.1016/j.neulet.2010.08.074
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author Swanwick, Richard S.
Pristerá, Alessandro
Okuse, Kenji
author_facet Swanwick, Richard S.
Pristerá, Alessandro
Okuse, Kenji
author_sort Swanwick, Richard S.
collection PubMed
description The α-subunit of tetrodotoxin-resistant voltage-gated sodium channel Na(V)1.8 is selectively expressed in sensory neurons. It has been reported that Na(V)1.8 is involved in the transmission of nociceptive information from sensory neurons to the central nervous system in nociceptive [1] and neuropathic [24] pain conditions. Thus Na(V)1.8 has been a promising target to treat chronic pain. Here we discuss the recent advances in the study of trafficking mechanism of Na(V)1.8. These pieces of information are particularly important as such trafficking machinery could be new targets for painkillers.
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spelling pubmed-29778482010-12-07 The trafficking of Na(V)1.8 Swanwick, Richard S. Pristerá, Alessandro Okuse, Kenji Neurosci Lett Review The α-subunit of tetrodotoxin-resistant voltage-gated sodium channel Na(V)1.8 is selectively expressed in sensory neurons. It has been reported that Na(V)1.8 is involved in the transmission of nociceptive information from sensory neurons to the central nervous system in nociceptive [1] and neuropathic [24] pain conditions. Thus Na(V)1.8 has been a promising target to treat chronic pain. Here we discuss the recent advances in the study of trafficking mechanism of Na(V)1.8. These pieces of information are particularly important as such trafficking machinery could be new targets for painkillers. Elsevier Scientific Publishers Ireland 2010-12-10 /pmc/articles/PMC2977848/ /pubmed/20816723 http://dx.doi.org/10.1016/j.neulet.2010.08.074 Text en © 2010 Elsevier Ireland Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Review
Swanwick, Richard S.
Pristerá, Alessandro
Okuse, Kenji
The trafficking of Na(V)1.8
title The trafficking of Na(V)1.8
title_full The trafficking of Na(V)1.8
title_fullStr The trafficking of Na(V)1.8
title_full_unstemmed The trafficking of Na(V)1.8
title_short The trafficking of Na(V)1.8
title_sort trafficking of na(v)1.8
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977848/
https://www.ncbi.nlm.nih.gov/pubmed/20816723
http://dx.doi.org/10.1016/j.neulet.2010.08.074
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