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Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency

OBJECTIVE: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency (ORD) present with disordered sex development and glucocorticoid deficiency. This is due to disruption of electron transfer from mutant POR to microsomal cytochrome P450 (CYP) enzymes that play a key...

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Detalles Bibliográficos
Autores principales:	Tomalik-Scharte, Dorota, Maiter, Dominique, Kirchheiner, Julia, Ivison, Hannah E, Fuhr, Uwe, Arlt, Wiebke
Formato:	Texto
Lenguaje:	English
Publicado:	BioScientifica 2010
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977993/ https://www.ncbi.nlm.nih.gov/pubmed/20844025 http://dx.doi.org/10.1530/EJE-10-0764

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