Deletion of the Basement Membrane Heparan Sulfate Proteoglycan Type XVIII Collagen Causes Hypertriglyceridemia in Mice and Humans

BACKGROUND: Lipoprotein lipase (Lpl) acts on triglyceride-rich lipoproteins in the peripheral circulation, liberating free fatty acids for energy metabolism or storage. This essential enzyme is synthesized in parenchymal cells of adipose tissue, heart, and skeletal muscle and migrates to the luminal...

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Detalles Bibliográficos
Autores principales: Bishop, Joseph R., Passos-Bueno, Maria Rita, Fong, Loren, Stanford, Kristin I., Gonzales, Jon C., Yeh, Erika, Young, Stephen G., Bensadoun, Andre, Witztum, Joseph L., Esko, Jeffrey D., Moulton, Karen S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978080/
https://www.ncbi.nlm.nih.gov/pubmed/21085708
http://dx.doi.org/10.1371/journal.pone.0013919

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