Pre-Clinical Drug Prioritization via Prognosis-Guided Genetic Interaction Networks

The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Patient population heterogeneity and unpredictable physiology complicate pre-clinical cancer modeling efforts. We hypothesize that gene networks asso...

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Detalles Bibliográficos
Autores principales: Xiong, Jianghui, Liu, Juan, Rayner, Simon, Tian, Ze, Li, Yinghui, Chen, Shanguang
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978107/
https://www.ncbi.nlm.nih.gov/pubmed/21085674
http://dx.doi.org/10.1371/journal.pone.0013937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978107/
https://www.ncbi.nlm.nih.gov/pubmed/21085674
http://dx.doi.org/10.1371/journal.pone.0013937

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