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Pre-Clinical Drug Prioritization via Prognosis-Guided Genetic Interaction Networks
The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs. Patient population heterogeneity and unpredictable physiology complicate pre-clinical cancer modeling efforts. We hypothesize that gene networks asso...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978107/ https://www.ncbi.nlm.nih.gov/pubmed/21085674 http://dx.doi.org/10.1371/journal.pone.0013937 |