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Inhibition of 2A-mediated ‘cleavage’ of certain artificial polyproteins bearing N-terminal signal sequences

Where 2A oligopeptide sequences occur within ORFs, the formation of the glycyl-prolyl peptide bond at the C-terminus of (each) 2A does not occur. This property can be used to concatenate sequences encoding several proteins into a single ORF: each component of such an artificial polyprotein is genera...

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Detalles Bibliográficos
Autores principales:	de Felipe, Pablo, Luke, Garry A, Brown, Jeremy D, Ryan, Martin D
Formato:	Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978324/ https://www.ncbi.nlm.nih.gov/pubmed/19946875 http://dx.doi.org/10.1002/biot.200900134

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