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A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells

Telomeres protect chromosome ends from being recognized as double-stranded breaks. Telomeric function is ensured by the shelterin complex in which TRF2 protein is an essential player. The G-rich strand of telomere DNA can fold into G-quadruplex (G4) structure. Small molecules stabilizing G4 structur...

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Detalles Bibliográficos
Autores principales:	Gomez, Dennis, Guédin, Aurore, Mergny, Jean-Louis, Salles, Bernard, Riou, Jean-François, Teulade-Fichou, Marie-Paule, Calsou, Patrick
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978344/ https://www.ncbi.nlm.nih.gov/pubmed/20571083 http://dx.doi.org/10.1093/nar/gkq563

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