Modulation of thermal stability can enhance the potency of siRNA

During RNA-induced silencing complex (RISC) assembly the guide (or antisense) strand has to separate from its complementary passenger (or sense) strand to generate the active RISC complex. Although this process was found to be facilitated through sense strand cleavage, there is evidence for an alter...

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Detalles Bibliográficos
Autores principales: Addepalli, Haripriya, Meena, Peng, Chang G., Wang, Gang, Fan, Yupeng, Charisse, Klaus, Jayaprakash, K. Narayanannair, Rajeev, Kallanthottathil G., Pandey, Rajendra K., Lavine, Gary, Zhang, Ligang, Jahn-Hofmann, Kerstin, Hadwiger, Philipp, Manoharan, Muthiah, Maier, Martin A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Synthetic Biology and Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978349/
https://www.ncbi.nlm.nih.gov/pubmed/20610434
http://dx.doi.org/10.1093/nar/gkq568

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