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Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer

Tyrosine kinase (TK) fusions are attractive drug targets in cancers. However, rapid identification of these lesions has been hampered by experimental limitations. Our in silico analysis of known cancer-derived TK fusions revealed that most breakpoints occur within a defined region upstream of a cons...

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Detalles Bibliográficos
Autores principales:	Chmielecki, Juliann, Peifer, Martin, Jia, Peilin, Socci, Nicholas D., Hutchinson, Katherine, Viale, Agnes, Zhao, Zhongming, Thomas, Roman K., Pao, William
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978357/ https://www.ncbi.nlm.nih.gov/pubmed/20587502 http://dx.doi.org/10.1093/nar/gkq579

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