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Double-stranded DNA-templated cleavage of oligonucleotides containing a P3′→N5′ linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity

We recently reported double-stranded DNA-templated cleavage of oligonucleotides as a sequence-specific DNA-detecting method. In this method, triplex-forming oligonucleotides (TFOs) modified with 5′-amino-2′,4′-BNA were used as a DNA-detecting probe. This modification introduced a P3′→N5′ linkage (P–...

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Detalles Bibliográficos
Autores principales:	Ito, Kosuke Ramon, Kodama, Tetsuya, Tomizu, Masaharu, Negoro, Yoshinori, Orita, Ayako, Osaki, Tomohisa, Hosoki, Noritsugu, Tanaka, Takaya, Imanishi, Takeshi, Obika, Satoshi
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978371/ https://www.ncbi.nlm.nih.gov/pubmed/20615902 http://dx.doi.org/10.1093/nar/gkq600

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