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Solution-state structure of a fully alternately 2′-F/2′-OMe modified 42-nt dimeric siRNA construct

A high-resolution solution structure of a stable 42-nt RNA dimeric construct has been derived based on a high number of NMR observables including nuclear overhauser effects (NOEs), J-coupling constants and residual dipolar couplings (RDCs), which were all obtained with isotopically unlabeled molecul...

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Detalles Bibliográficos
Autores principales: Podbevsek, Peter, Allerson, Charles R., Bhat, Balkrishen, Plavec, Janez
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978378/
https://www.ncbi.nlm.nih.gov/pubmed/20624819
http://dx.doi.org/10.1093/nar/gkq621