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Solution-state structure of a fully alternately 2′-F/2′-OMe modified 42-nt dimeric siRNA construct
A high-resolution solution structure of a stable 42-nt RNA dimeric construct has been derived based on a high number of NMR observables including nuclear overhauser effects (NOEs), J-coupling constants and residual dipolar couplings (RDCs), which were all obtained with isotopically unlabeled molecul...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978378/ https://www.ncbi.nlm.nih.gov/pubmed/20624819 http://dx.doi.org/10.1093/nar/gkq621 |