A Naturally Occurring Variant in Human TLR9, P99L, Is Associated with Loss of CpG Oligonucleotide Responsiveness

The innate immune system employs Toll-like receptors (TLRs) for the detection of invading microorganisms based on distinct molecular patterns. For example, TLR9 is activated by microbial DNA and also by short therapeutic CpG-containing oligonucleotides (CpG-ODN). TLR9 activation leads to the product...

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Detalles Bibliográficos
Autores principales: Kubarenko, Andriy V., Ranjan, Satish, Rautanen, Anna, Mills, Tara C., Wong, Sunny, Vannberg, Fredrik, Neumaier, Michael, Bekeredjian-Ding, Isabelle, Hill, Adrian V. S., Ahmad-Nejad, Parviz, Weber, Alexander N. R.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978577/
https://www.ncbi.nlm.nih.gov/pubmed/20843814
http://dx.doi.org/10.1074/jbc.M110.117200

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