Cargando…

Functional Genomics Complements Quantitative Genetics in Identifying Disease-Gene Associations

An ultimate goal of genetic research is to understand the connection between genotype and phenotype in order to improve the diagnosis and treatment of diseases. The quantitative genetics field has developed a suite of statistical methods to associate genetic loci with diseases and phenotypes, includ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guan, Yuanfang, Ackert-Bicknell, Cheryl L., Kell, Braden, Troyanskaya, Olga G., Hibbs, Matthew A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978695/ https://www.ncbi.nlm.nih.gov/pubmed/21085640 http://dx.doi.org/10.1371/journal.pcbi.1000991

Ejemplares similares

Tissue-Specific Functional Networks for Prioritizing Phenotype and Disease Genes
por: Guan, Yuanfang, et al.
Publicado: (2012)

The Genetics of PPARG and the Skeleton
por: Ackert-Bicknell, Cheryl, et al.
Publicado: (2006)

Systematic Planning of Genome-Scale Experiments in Poorly Studied Species
por: Guan, Yuanfang, et al.
Publicado: (2010)

Finding function: evaluation methods for functional genomic data
por: Myers, Chad L, et al.
Publicado: (2006)

Mouse Models and Online Resources for Functional Analysis of Osteoporosis Genome-Wide Association Studies
por: Maynard, Robert D., et al.
Publicado: (2019)

Comparative gene expression between two yeast species
por: Guan, Yuanfang, et al.
Publicado: (2013)

Functional screens refine height GWAS loci
por: Ackert-Bicknell, Cheryl L.
Publicado: (2023)

Canonical A-to-I and C-to-U RNA Editing Is Enriched at 3′UTRs and microRNA Target Sites in Multiple Mouse Tissues
por: Gu, Tongjun, et al.
Publicado: (2012)

IMP: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks
por: Wong, Aaron K., et al.
Publicado: (2012)

Predicting gene function in a hierarchical context with an ensemble of classifiers
por: Guan, Yuanfang, et al.
Publicado: (2008)

GOLEM: an interactive graph-based gene-ontology navigation and analysis tool
por: Sealfon, Rachel SG, et al.
Publicado: (2006)

Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass
por: Mesner, Larry D., et al.
Publicado: (2019)

Discovery of biological networks from diverse functional genomic data
por: Myers, Chad L, et al.
Publicado: (2005)

Mouse BMD Quantitative Trait Loci Show Improved Concordance With Human Genome-wide Association Loci When Recalculated on a New, Common Mouse Genetic Map
por: Ackert-Bicknell, Cheryl L, et al.
Publicado: (2010)

Visualization methods for statistical analysis of microarray clusters
por: Hibbs, Matthew A, et al.
Publicado: (2005)

Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination
por: Pallares, Luisa F., et al.
Publicado: (2015)

Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass
por: Doolittle, Madison L., et al.
Publicado: (2020)

Computationally Driven, Quantitative Experiments Discover Genes Required for Mitochondrial Biogenesis
por: Hess, David C., et al.
Publicado: (2009)

A Genomewide Functional Network for the Laboratory Mouse
por: Guan, Yuanfang, et al.
Publicado: (2008)

Differences in articular hip cartilage gene expression between femoroacetabular impingement (FAI) and end-stage hip osteoarthritis
por: Reuter, John, et al.
Publicado: (2020)

Global Quantitative Modeling of Chromatin Factor Interactions
por: Zhou, Jian, et al.
Publicado: (2014)

Semi-Quantitative Multiplex Profiling of the Complement System Identifies Associations of Complement Proteins with Genetic Variants and Metabolites in Age-Related Macular Degeneration
por: Acar, I. Erkin, et al.
Publicado: (2021)

Simultaneous Genome-Wide Inference of Physical, Genetic, Regulatory, and Functional Pathway Components
por: Park, Christopher Y., et al.
Publicado: (2010)

Nucleosome-coupled expression differences in closely-related species
por: Guan, Yuanfang, et al.
Publicado: (2011)

A computational approach for identification of core modules from a co-expression network and GWAS data
por: Sabik, Olivia L., et al.
Publicado: (2021)

GIANT 2.0: genome-scale integrated analysis of gene networks in tissues
por: Wong, Aaron K, et al.
Publicado: (2018)

Global analysis of gene function in yeast by quantitative phenotypic profiling
por: Brown, James A, et al.
Publicado: (2006)

Functional Knowledge Transfer for High-accuracy Prediction of Under-studied Biological Processes
por: Park, Christopher Y., et al.
Publicado: (2013)

Directing Experimental Biology: A Case Study in Mitochondrial Biogenesis
por: Hibbs, Matthew A., et al.
Publicado: (2009)

The Sleipnir library for computational functional genomics
por: Huttenhower, Curtis, et al.
Publicado: (2008)

Nearest Neighbor Networks: clustering expression data based on gene neighborhoods
por: Huttenhower, Curtis, et al.
Publicado: (2007)

Deep learning identifies erroneous microarray-based, gene-level conclusions in literature
por: Qin, Yanan, et al.
Publicado: (2021)

Application of Genomic and Quantitative Genetic Tools to Identify Candidate Resistance Genes for Brown Rot Resistance in Peach
por: Martínez-García, Pedro J., et al.
Publicado: (2013)

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken
por: Johnsson, Martin, et al.
Publicado: (2015)

Quantitative multiplex profiling of the complement system to diagnose complement‐mediated diseases
por: Willems, Esther, et al.
Publicado: (2020)

GIANT API: an application programming interface for functional genomics
por: Roberts, Andrew M., et al.
Publicado: (2016)

QUANTITATIVE STUDIES ON THE PROPERDIN-COMPLEMENT SYSTEM
por: Leon, Myron A.
Publicado: (1956)

Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span
por: Bogue, Molly A., et al.
Publicado: (2016)

Assessing the functional structure of genomic data
por: Huttenhower, C., et al.
Publicado: (2008)

Rapid genome sequencing identifies novel variants in complement factor I
por: Rodriguez, Katherine M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_prnibplakke1p8n4ui03ob2nk1