Synaptic Defects in the Spinal and Neuromuscular Circuitry in a Mouse Model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a major genetic cause of death in childhood characterized by marked muscle weakness. To investigate mechanisms underlying motor impairment in SMA, we examined the spinal and neuromuscular circuitry governing hindlimb ambulatory behavior in SMA model mice (SMNΔ7). In...

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Detalles Bibliográficos
Autores principales: Ling, Karen K. Y., Lin, Ming-Yi, Zingg, Brian, Feng, Zhihua, Ko, Chien-Ping
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978709/
https://www.ncbi.nlm.nih.gov/pubmed/21085654
http://dx.doi.org/10.1371/journal.pone.0015457

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