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Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B

BACKGROUND: Measuring liver stiffness is becoming more popular as a non-invasive tool for assessing liver fibrosis. AIM: To assess the effect of severe hepatitis B flare on liver stiffness and determine factors that correlate with liver stiffness measurements. METHODS: Twenty-nine patients with seve...

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Autores principales: Fung, James, Lai, Ching-Lung, But, David, Hsu, Axel, Seto, Wai-Kay, Cheng, Charles, Wong, Danny Ka-Ho, Yuen, Man-Fung
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978896/
https://www.ncbi.nlm.nih.gov/pubmed/21286342
http://dx.doi.org/10.1007/s12072-010-9189-z
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author Fung, James
Lai, Ching-Lung
But, David
Hsu, Axel
Seto, Wai-Kay
Cheng, Charles
Wong, Danny Ka-Ho
Yuen, Man-Fung
author_facet Fung, James
Lai, Ching-Lung
But, David
Hsu, Axel
Seto, Wai-Kay
Cheng, Charles
Wong, Danny Ka-Ho
Yuen, Man-Fung
author_sort Fung, James
collection PubMed
description BACKGROUND: Measuring liver stiffness is becoming more popular as a non-invasive tool for assessing liver fibrosis. AIM: To assess the effect of severe hepatitis B flare on liver stiffness and determine factors that correlate with liver stiffness measurements. METHODS: Twenty-nine patients with severe hepatitis B flare (ALT > 10 × upper limit of normal) were followed up for 1 year. Serial transient elastography was performed at the time of flare, 3–6, and 12 months after flare. RESULTS: At the time of flare, the median liver stiffness was 16.8 kPa, with no patients having normal liver stiffness (<6 kPa). There was a significant decrease in liver stiffness from baseline to 3–6 months (16.8 vs. 7.9 kPa, respectively, P < 0.001), and a further smaller decline from 3–6 to 12 months (7.9 vs. 6.9 kPa, respectively, P = 0.039). By 12 months, 10 (34%) had normalized their liver stiffness. Baseline parameters which correlated with liver stiffness include bilirubin, ALT, albumin, prothrombin time and platelet levels (all P < 0.05). CONCLUSION: Liver stiffness was increased in patients with severe hepatitis B flares, with return to near normal levels by 6 months. Transient elastography for proper assessment of liver fibrosis should be performed at least 6 months after flare.
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spelling pubmed-29788962010-12-08 Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B Fung, James Lai, Ching-Lung But, David Hsu, Axel Seto, Wai-Kay Cheng, Charles Wong, Danny Ka-Ho Yuen, Man-Fung Hepatol Int Original Article BACKGROUND: Measuring liver stiffness is becoming more popular as a non-invasive tool for assessing liver fibrosis. AIM: To assess the effect of severe hepatitis B flare on liver stiffness and determine factors that correlate with liver stiffness measurements. METHODS: Twenty-nine patients with severe hepatitis B flare (ALT > 10 × upper limit of normal) were followed up for 1 year. Serial transient elastography was performed at the time of flare, 3–6, and 12 months after flare. RESULTS: At the time of flare, the median liver stiffness was 16.8 kPa, with no patients having normal liver stiffness (<6 kPa). There was a significant decrease in liver stiffness from baseline to 3–6 months (16.8 vs. 7.9 kPa, respectively, P < 0.001), and a further smaller decline from 3–6 to 12 months (7.9 vs. 6.9 kPa, respectively, P = 0.039). By 12 months, 10 (34%) had normalized their liver stiffness. Baseline parameters which correlated with liver stiffness include bilirubin, ALT, albumin, prothrombin time and platelet levels (all P < 0.05). CONCLUSION: Liver stiffness was increased in patients with severe hepatitis B flares, with return to near normal levels by 6 months. Transient elastography for proper assessment of liver fibrosis should be performed at least 6 months after flare. Springer-Verlag 2010-07-24 /pmc/articles/PMC2978896/ /pubmed/21286342 http://dx.doi.org/10.1007/s12072-010-9189-z Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Fung, James
Lai, Ching-Lung
But, David
Hsu, Axel
Seto, Wai-Kay
Cheng, Charles
Wong, Danny Ka-Ho
Yuen, Man-Fung
Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B
title Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B
title_full Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B
title_fullStr Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B
title_full_unstemmed Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B
title_short Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B
title_sort reduction of liver stiffness following resolution of acute flares of chronic hepatitis b
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978896/
https://www.ncbi.nlm.nih.gov/pubmed/21286342
http://dx.doi.org/10.1007/s12072-010-9189-z
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