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4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol
The title compound, C(20)H(20)Br(2)ClN(3)O(3), was synthesized by the condensation reaction of 2-chloro-5-nitrobenzaldehyde with 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol in a methanol solution. There are two independent molecules in the asymmetric unit and in one molecule the atoms of t...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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International Union of Crystallography
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979269/ https://www.ncbi.nlm.nih.gov/pubmed/21579236 http://dx.doi.org/10.1107/S1600536810015023 |
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author | Wang, Zhi-Gang Xia, Zong-Lin Wang, Rong Wang, Ming-Li |
author_facet | Wang, Zhi-Gang Xia, Zong-Lin Wang, Rong Wang, Ming-Li |
author_sort | Wang, Zhi-Gang |
collection | PubMed |
description | The title compound, C(20)H(20)Br(2)ClN(3)O(3), was synthesized by the condensation reaction of 2-chloro-5-nitrobenzaldehyde with 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol in a methanol solution. There are two independent molecules in the asymmetric unit and in one molecule the atoms of the cyclohexane ring are disordered over two sets of sites with refined occupancies of 0.657 (12) and 0.343 (12). The dihedral angle between the two benzene rings is 89.5 (2)° in one molecule and 82.9 (2)° in the other. In the crystal structure, intermolecular N—H⋯O and O—H⋯O hydrogen bonds link the molecules into chains propagating along [01[Image: see text]]. |
format | Text |
id | pubmed-2979269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-29792692010-12-30 4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol Wang, Zhi-Gang Xia, Zong-Lin Wang, Rong Wang, Ming-Li Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(20)H(20)Br(2)ClN(3)O(3), was synthesized by the condensation reaction of 2-chloro-5-nitrobenzaldehyde with 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol in a methanol solution. There are two independent molecules in the asymmetric unit and in one molecule the atoms of the cyclohexane ring are disordered over two sets of sites with refined occupancies of 0.657 (12) and 0.343 (12). The dihedral angle between the two benzene rings is 89.5 (2)° in one molecule and 82.9 (2)° in the other. In the crystal structure, intermolecular N—H⋯O and O—H⋯O hydrogen bonds link the molecules into chains propagating along [01[Image: see text]]. International Union of Crystallography 2010-04-28 /pmc/articles/PMC2979269/ /pubmed/21579236 http://dx.doi.org/10.1107/S1600536810015023 Text en © Wang et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Wang, Zhi-Gang Xia, Zong-Lin Wang, Rong Wang, Ming-Li 4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol |
title | 4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol |
title_full | 4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol |
title_fullStr | 4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol |
title_full_unstemmed | 4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol |
title_short | 4-[6,8-Dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol |
title_sort | 4-[6,8-dibromo-2-(2-chloro-5-nitrophenyl)-1,2,3,4-tetrahydroquinazolin-3-yl]cyclohexanol |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979269/ https://www.ncbi.nlm.nih.gov/pubmed/21579236 http://dx.doi.org/10.1107/S1600536810015023 |
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