Prasugrel, a new medicine for preventing blockages in the arteries

Prasugrel {systematic name: 5-[(2-cyclo­propyl­carbon­yl)(2-fluoro­phen­yl)meth­yl]-4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-2-yl acetate}, C(20)H(20)FNO(3)S, is a new third-generation thienopyridine which was recently approved for clinical use as a more potent blocker of the platelet P2Y(12) recept...

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Detalles Bibliográficos
Autores principales: Wang, Zhi-Mei, Zhao, Jian, Xu, Gang
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979458/
https://www.ncbi.nlm.nih.gov/pubmed/21579440
http://dx.doi.org/10.1107/S1600536810017095
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author Wang, Zhi-Mei
Zhao, Jian
Xu, Gang
author_facet Wang, Zhi-Mei
Zhao, Jian
Xu, Gang
author_sort Wang, Zhi-Mei
collection PubMed
description Prasugrel {systematic name: 5-[(2-cyclo­propyl­carbon­yl)(2-fluoro­phen­yl)meth­yl]-4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-2-yl acetate}, C(20)H(20)FNO(3)S, is a new third-generation thienopyridine which was recently approved for clinical use as a more potent blocker of the platelet P2Y(12) receptor than clopidogrel, which was previously used for this purpose. The mol­ecule features a tetra­hydro­thienopyridine system with the tetra­hydro­pyridine ring showing a half-chair conformation; the dihedral angle formed by the the planes of the benzene and thio­phene rings is 83.17 (3)°.
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spelling pubmed-29794582010-12-30 Prasugrel, a new medicine for preventing blockages in the arteries Wang, Zhi-Mei Zhao, Jian Xu, Gang Acta Crystallogr Sect E Struct Rep Online Organic Papers Prasugrel {systematic name: 5-[(2-cyclo­propyl­carbon­yl)(2-fluoro­phen­yl)meth­yl]-4,5,6,7-tetra­hydro­thieno[3,2-c]pyridin-2-yl acetate}, C(20)H(20)FNO(3)S, is a new third-generation thienopyridine which was recently approved for clinical use as a more potent blocker of the platelet P2Y(12) receptor than clopidogrel, which was previously used for this purpose. The mol­ecule features a tetra­hydro­thienopyridine system with the tetra­hydro­pyridine ring showing a half-chair conformation; the dihedral angle formed by the the planes of the benzene and thio­phene rings is 83.17 (3)°. International Union of Crystallography 2010-05-15 /pmc/articles/PMC2979458/ /pubmed/21579440 http://dx.doi.org/10.1107/S1600536810017095 Text en © Wang et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Wang, Zhi-Mei
Zhao, Jian
Xu, Gang
Prasugrel, a new medicine for preventing blockages in the arteries
title Prasugrel, a new medicine for preventing blockages in the arteries
title_full Prasugrel, a new medicine for preventing blockages in the arteries
title_fullStr Prasugrel, a new medicine for preventing blockages in the arteries
title_full_unstemmed Prasugrel, a new medicine for preventing blockages in the arteries
title_short Prasugrel, a new medicine for preventing blockages in the arteries
title_sort prasugrel, a new medicine for preventing blockages in the arteries
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979458/
https://www.ncbi.nlm.nih.gov/pubmed/21579440
http://dx.doi.org/10.1107/S1600536810017095
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AT xugang prasugrelanewmedicineforpreventingblockagesinthearteries

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