5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione

The title compound, C(20)H(25)N(3)O(2), is a new amonafide analogue, which exhibits anti­tumor activity. The asymmetric unit contains two mol­ecules with similar conformations for the substituted aliphatic chains. The two independent mol­ecules form dmers through N—H⋯N hydrogen bonds. The crystal st...

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Detalles Bibliográficos
Autor principal: Xie, Li-Juan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979579/
https://www.ncbi.nlm.nih.gov/pubmed/21579523
http://dx.doi.org/10.1107/S1600536810018702
Descripción
Sumario:The title compound, C(20)H(25)N(3)O(2), is a new amonafide analogue, which exhibits anti­tumor activity. The asymmetric unit contains two mol­ecules with similar conformations for the substituted aliphatic chains. The two independent mol­ecules form dmers through N—H⋯N hydrogen bonds. The crystal structure is stabilized via π–π stacking inter­actions, the shortest centroid–centroid separation between six-membered rings being 3.673 (2) Å.

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