5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione

The title compound, C(20)H(25)N(3)O(2), is a new amonafide analogue, which exhibits anti­tumor activity. The asymmetric unit contains two mol­ecules with similar conformations for the substituted aliphatic chains. The two independent mol­ecules form dmers through N—H⋯N hydrogen bonds. The crystal st...

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Detalles Bibliográficos
Autor principal: Xie, Li-Juan
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979579/
https://www.ncbi.nlm.nih.gov/pubmed/21579523
http://dx.doi.org/10.1107/S1600536810018702
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author Xie, Li-Juan
author_facet Xie, Li-Juan
author_sort Xie, Li-Juan
collection PubMed
description The title compound, C(20)H(25)N(3)O(2), is a new amonafide analogue, which exhibits anti­tumor activity. The asymmetric unit contains two mol­ecules with similar conformations for the substituted aliphatic chains. The two independent mol­ecules form dmers through N—H⋯N hydrogen bonds. The crystal structure is stabilized via π–π stacking inter­actions, the shortest centroid–centroid separation between six-membered rings being 3.673 (2) Å.
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spelling pubmed-29795792010-12-30 5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione Xie, Li-Juan Acta Crystallogr Sect E Struct Rep Online Organic Papers The title compound, C(20)H(25)N(3)O(2), is a new amonafide analogue, which exhibits anti­tumor activity. The asymmetric unit contains two mol­ecules with similar conformations for the substituted aliphatic chains. The two independent mol­ecules form dmers through N—H⋯N hydrogen bonds. The crystal structure is stabilized via π–π stacking inter­actions, the shortest centroid–centroid separation between six-membered rings being 3.673 (2) Å. International Union of Crystallography 2010-05-26 /pmc/articles/PMC2979579/ /pubmed/21579523 http://dx.doi.org/10.1107/S1600536810018702 Text en © Li-Juan Xie 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Xie, Li-Juan
5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione
title 5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione
title_full 5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione
title_fullStr 5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione
title_full_unstemmed 5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione
title_short 5-Butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1H-benz[de]isoquinoline-1,3(2H)-dione
title_sort 5-butyl­amino-2-[2-(dimethyl­amino)eth­yl]-1h-benz[de]isoquinoline-1,3(2h)-dione
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979579/
https://www.ncbi.nlm.nih.gov/pubmed/21579523
http://dx.doi.org/10.1107/S1600536810018702
work_keys_str_mv AT xielijuan 5butylamino22dimethylaminoethyl1hbenzdeisoquinoline132hdione

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