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Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
In the title compound, C(14)H(15)NO(6)S, the thiazine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak intermolecular C—H⋯O hydrogen-bonding interactions, giving rise to a two-dimensional sheet packing motif. The CH(2) group in the methoxy linker t...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979684/ https://www.ncbi.nlm.nih.gov/pubmed/21579762 http://dx.doi.org/10.1107/S1600536810000668 |
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author | Ahmad, Matloob Siddiqui, Hamid Latif Zia-ur-Rehman, Muhammad Elsegood, Mark R. J. Weaver, George W. |
author_facet | Ahmad, Matloob Siddiqui, Hamid Latif Zia-ur-Rehman, Muhammad Elsegood, Mark R. J. Weaver, George W. |
author_sort | Ahmad, Matloob |
collection | PubMed |
description | In the title compound, C(14)H(15)NO(6)S, the thiazine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak intermolecular C—H⋯O hydrogen-bonding interactions, giving rise to a two-dimensional sheet packing motif. The CH(2) group in the methoxy linker to the oxirane ring, and the CH group in that ring, exhibit twofold positional disorder. The three-membered oxirane ring is twisted approximately perpendicular with respect to thiazine ring (dihedral angle = 60/86° for the major/minor disorder components). 1,2-Benzothiazines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis. |
format | Text |
id | pubmed-2979684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-29796842010-12-30 Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide Ahmad, Matloob Siddiqui, Hamid Latif Zia-ur-Rehman, Muhammad Elsegood, Mark R. J. Weaver, George W. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(14)H(15)NO(6)S, the thiazine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak intermolecular C—H⋯O hydrogen-bonding interactions, giving rise to a two-dimensional sheet packing motif. The CH(2) group in the methoxy linker to the oxirane ring, and the CH group in that ring, exhibit twofold positional disorder. The three-membered oxirane ring is twisted approximately perpendicular with respect to thiazine ring (dihedral angle = 60/86° for the major/minor disorder components). 1,2-Benzothiazines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis. International Union of Crystallography 2010-01-09 /pmc/articles/PMC2979684/ /pubmed/21579762 http://dx.doi.org/10.1107/S1600536810000668 Text en © Ahmad et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Ahmad, Matloob Siddiqui, Hamid Latif Zia-ur-Rehman, Muhammad Elsegood, Mark R. J. Weaver, George W. Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide |
title | Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide |
title_full | Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide |
title_fullStr | Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide |
title_full_unstemmed | Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide |
title_short | Methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide |
title_sort | methyl 2-methyl-4-(oxiran-2-ylmethoxy)-2h-1,2-benzothiazine-3-carboxylate 1,1-dioxide |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979684/ https://www.ncbi.nlm.nih.gov/pubmed/21579762 http://dx.doi.org/10.1107/S1600536810000668 |
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