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Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide

In the title compound, C(14)H(15)NO(6)S, the thia­zine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak inter­molecular C—H⋯O hydrogen-bonding inter­actions, giving rise to a two-dimensional sheet packing motif. The CH(2) group in the meth­oxy linker t...

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Autores principales: Ahmad, Matloob, Siddiqui, Hamid Latif, Zia-ur-Rehman, Muhammad, Elsegood, Mark R. J., Weaver, George W.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979684/
https://www.ncbi.nlm.nih.gov/pubmed/21579762
http://dx.doi.org/10.1107/S1600536810000668
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author Ahmad, Matloob
Siddiqui, Hamid Latif
Zia-ur-Rehman, Muhammad
Elsegood, Mark R. J.
Weaver, George W.
author_facet Ahmad, Matloob
Siddiqui, Hamid Latif
Zia-ur-Rehman, Muhammad
Elsegood, Mark R. J.
Weaver, George W.
author_sort Ahmad, Matloob
collection PubMed
description In the title compound, C(14)H(15)NO(6)S, the thia­zine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak inter­molecular C—H⋯O hydrogen-bonding inter­actions, giving rise to a two-dimensional sheet packing motif. The CH(2) group in the meth­oxy linker to the oxirane ring, and the CH group in that ring, exhibit twofold positional disorder. The three-membered oxirane ring is twisted approximately perpendicular with respect to thia­zine ring (dihedral angle = 60/86° for the major/minor disorder components). 1,2-Benzothia­zines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis.
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spelling pubmed-29796842010-12-30 Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide Ahmad, Matloob Siddiqui, Hamid Latif Zia-ur-Rehman, Muhammad Elsegood, Mark R. J. Weaver, George W. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(14)H(15)NO(6)S, the thia­zine ring adopts a distorted half-chair conformation. The structure displays several cooperative weak inter­molecular C—H⋯O hydrogen-bonding inter­actions, giving rise to a two-dimensional sheet packing motif. The CH(2) group in the meth­oxy linker to the oxirane ring, and the CH group in that ring, exhibit twofold positional disorder. The three-membered oxirane ring is twisted approximately perpendicular with respect to thia­zine ring (dihedral angle = 60/86° for the major/minor disorder components). 1,2-Benzothia­zines of this kind have a wide range of biological activities and are mainly used as medicines in the treatment of inflammation and rheumatoid arthritis. International Union of Crystallography 2010-01-09 /pmc/articles/PMC2979684/ /pubmed/21579762 http://dx.doi.org/10.1107/S1600536810000668 Text en © Ahmad et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Ahmad, Matloob
Siddiqui, Hamid Latif
Zia-ur-Rehman, Muhammad
Elsegood, Mark R. J.
Weaver, George W.
Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide
title Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide
title_full Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide
title_fullStr Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide
title_full_unstemmed Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide
title_short Methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2H-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide
title_sort methyl 2-methyl-4-(oxiran-2-ylmeth­oxy)-2h-1,2-benzothia­zine-3-carboxyl­ate 1,1-dioxide
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979684/
https://www.ncbi.nlm.nih.gov/pubmed/21579762
http://dx.doi.org/10.1107/S1600536810000668
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