(+)-Hexacyclinol

A sample of the title compound [systematic name: (1aS,2aS,3S,5aS,6aS,7R,7aS,7bS,8R,8aS,10R)-7-hydr­oxy-3-(1-meth­oxy-1-methyl­ethyl)-10-(2-methyl-1-propen­yl)-1a,5a,6a,7,7a,7b,8,8a-octa­hydro-2H-8,2a-(epoxy­methano)phenanthro[2,3-b:6,7-b′]bis­oxirene-2,5(3H)-dione], C(23)H(28)O(7), was generated by...

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Detalles Bibliográficos
Autores principales: Pinkerton, David M., Banwell, Martin G., Willis, Anthony C.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979687/
https://www.ncbi.nlm.nih.gov/pubmed/21579771
http://dx.doi.org/10.1107/S1600536810000620
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author Pinkerton, David M.
Banwell, Martin G.
Willis, Anthony C.
author_facet Pinkerton, David M.
Banwell, Martin G.
Willis, Anthony C.
author_sort Pinkerton, David M.
collection PubMed
description A sample of the title compound [systematic name: (1aS,2aS,3S,5aS,6aS,7R,7aS,7bS,8R,8aS,10R)-7-hydr­oxy-3-(1-meth­oxy-1-methyl­ethyl)-10-(2-methyl-1-propen­yl)-1a,5a,6a,7,7a,7b,8,8a-octa­hydro-2H-8,2a-(epoxy­methano)phenanthro[2,3-b:6,7-b′]bis­oxirene-2,5(3H)-dione], C(23)H(28)O(7), was generated by enanti­oselective synthesis. There are three mol­ecules of the compound in the crystallographic asymmetric unit. Hydrogen bonding between alcohol H atoms and keto groups of adjacent mol­ecules appears to stabilize the structure. The compound is enanti­omerically pure but the absolute configuration could not be determined directly in this study. Accordingly, the illustrated configuration was assigned on the basis of the nature of the chiral nonracemic precursor used in the synthesis.
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spelling pubmed-29796872010-12-30 (+)-Hexacyclinol Pinkerton, David M. Banwell, Martin G. Willis, Anthony C. Acta Crystallogr Sect E Struct Rep Online Organic Papers A sample of the title compound [systematic name: (1aS,2aS,3S,5aS,6aS,7R,7aS,7bS,8R,8aS,10R)-7-hydr­oxy-3-(1-meth­oxy-1-methyl­ethyl)-10-(2-methyl-1-propen­yl)-1a,5a,6a,7,7a,7b,8,8a-octa­hydro-2H-8,2a-(epoxy­methano)phenanthro[2,3-b:6,7-b′]bis­oxirene-2,5(3H)-dione], C(23)H(28)O(7), was generated by enanti­oselective synthesis. There are three mol­ecules of the compound in the crystallographic asymmetric unit. Hydrogen bonding between alcohol H atoms and keto groups of adjacent mol­ecules appears to stabilize the structure. The compound is enanti­omerically pure but the absolute configuration could not be determined directly in this study. Accordingly, the illustrated configuration was assigned on the basis of the nature of the chiral nonracemic precursor used in the synthesis. International Union of Crystallography 2010-01-13 /pmc/articles/PMC2979687/ /pubmed/21579771 http://dx.doi.org/10.1107/S1600536810000620 Text en © Pinkerton et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Pinkerton, David M.
Banwell, Martin G.
Willis, Anthony C.
(+)-Hexacyclinol
title (+)-Hexacyclinol
title_full (+)-Hexacyclinol
title_fullStr (+)-Hexacyclinol
title_full_unstemmed (+)-Hexacyclinol
title_short (+)-Hexacyclinol
title_sort (+)-hexacyclinol
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979687/
https://www.ncbi.nlm.nih.gov/pubmed/21579771
http://dx.doi.org/10.1107/S1600536810000620
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AT banwellmarting hexacyclinol
AT willisanthonyc hexacyclinol

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