(1R,3S,5R,6S)-6-Hydr­oxy-3-tosyl­oxy­tropan-8-ium chloride

The title compound, C(15)H(22)NO(4)S(+)·Cl(−), is a hydrolysis product of lesatropane [(1R,3S,5R,6S)-6-acet­oxy-3-tosyl­oxytropane] hydro­chloride, a potential anti­glaucoma agent. As in lesatropane, the piperidine and pyrrolidine rings in the title compound adopt chair and envelope conformations, r...

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Detalles Bibliográficos
Autores principales: Yu, Nian-Xi, Yang, Li-Min, Lu, Yang
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2979886/
https://www.ncbi.nlm.nih.gov/pubmed/21579747
http://dx.doi.org/10.1107/S1600536809055366
Descripción
Sumario:The title compound, C(15)H(22)NO(4)S(+)·Cl(−), is a hydrolysis product of lesatropane [(1R,3S,5R,6S)-6-acet­oxy-3-tosyl­oxytropane] hydro­chloride, a potential anti­glaucoma agent. As in lesatropane, the piperidine and pyrrolidine rings in the title compound adopt chair and envelope conformations, respectively. There are two mol­ecules in the unit cell with similar conformations. The crystal structure is stabilized by inter­molecular O—H⋯Cl and N—H⋯Cl hydrogen bonds.

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