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2,4-Bis(2-fluoro­phen­yl)-1-methyl-3-aza­bicyclo­[3.3.1]nonan-9-one

The crystal structure of the title compound, C(21)H(21)F(2)NO, shows that the compound exists in a twin-chair conformation with an equatorial orientation of the ortho-fluoro­phenyl groups on either side of the secondary amino group. The title compound is a 1-methyl­ated analog of 2,4-bis­(2-fluoro­p...

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Detalles Bibliográficos
Autores principales: Parthiban, P., Ramkumar, V., Jeong, Yeon Tae
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980085/
https://www.ncbi.nlm.nih.gov/pubmed/21580078
http://dx.doi.org/10.1107/S1600536809053677
Descripción
Sumario:The crystal structure of the title compound, C(21)H(21)F(2)NO, shows that the compound exists in a twin-chair conformation with an equatorial orientation of the ortho-fluoro­phenyl groups on either side of the secondary amino group. The title compound is a 1-methyl­ated analog of 2,4-bis­(2-fluoro­phen­yl)-3-aza­bicyclo­[3.3.1]nonan-9-one; the two compound both exhibit the same stereochemistry but the orientation of the ortho-fluoro­phenyl rings differs slightly. In the title compound, the rings are orientated at a dihedral angle of 36.70 (3)° with respect to one another, whereas in the non-methyl analog, the angle is 25.68 (4)°. The crystal structure of the title compound is stabilized by an inter­molecular N—H⋯π inter­action and a weak C—H⋯F inter­action.