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Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate

The reaction of 1,5-dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione with ethyl azido­acetate in the presence of copper sulfate pentahydrate and sodium ascorbate leads to the formation of the title regioisomer, C(30)H(29)N(5)O(4), which features a phenyl­ene ring fused with a seven-membered diazepi...

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Detalles Bibliográficos
Autores principales: Jabli, Hind, Kandri Rodi, Y., Ladeira, Sonia, Essassi, El Mokhtar, Ng, Seik Weng
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980270/
https://www.ncbi.nlm.nih.gov/pubmed/21580016
http://dx.doi.org/10.1107/S1600536809052696
Descripción
Sumario:The reaction of 1,5-dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione with ethyl azido­acetate in the presence of copper sulfate pentahydrate and sodium ascorbate leads to the formation of the title regioisomer, C(30)H(29)N(5)O(4), which features a phenyl­ene ring fused with a seven-membered diazepinyl ring. The latter ring adopts a boat conformation (with the methyl­triazolylacetate-bearing C atom as the prow and the fused-ring C atoms as the stern). The benzyl groups connected to the diazepinyl ring jprotrude from the sides; the methyl­triazolylacetate substituent occupies an axial position.