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Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate

The reaction of 1,5-dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione with ethyl azido­acetate in the presence of copper sulfate pentahydrate and sodium ascorbate leads to the formation of the title regioisomer, C(30)H(29)N(5)O(4), which features a phenyl­ene ring fused with a seven-membered diazepi...

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Autores principales: Jabli, Hind, Kandri Rodi, Y., Ladeira, Sonia, Essassi, El Mokhtar, Ng, Seik Weng
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980270/
https://www.ncbi.nlm.nih.gov/pubmed/21580016
http://dx.doi.org/10.1107/S1600536809052696
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author Jabli, Hind
Kandri Rodi, Y.
Ladeira, Sonia
Essassi, El Mokhtar
Ng, Seik Weng
author_facet Jabli, Hind
Kandri Rodi, Y.
Ladeira, Sonia
Essassi, El Mokhtar
Ng, Seik Weng
author_sort Jabli, Hind
collection PubMed
description The reaction of 1,5-dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione with ethyl azido­acetate in the presence of copper sulfate pentahydrate and sodium ascorbate leads to the formation of the title regioisomer, C(30)H(29)N(5)O(4), which features a phenyl­ene ring fused with a seven-membered diazepinyl ring. The latter ring adopts a boat conformation (with the methyl­triazolylacetate-bearing C atom as the prow and the fused-ring C atoms as the stern). The benzyl groups connected to the diazepinyl ring jprotrude from the sides; the methyl­triazolylacetate substituent occupies an axial position.
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spelling pubmed-29802702010-12-30 Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate Jabli, Hind Kandri Rodi, Y. Ladeira, Sonia Essassi, El Mokhtar Ng, Seik Weng Acta Crystallogr Sect E Struct Rep Online Organic Papers The reaction of 1,5-dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione with ethyl azido­acetate in the presence of copper sulfate pentahydrate and sodium ascorbate leads to the formation of the title regioisomer, C(30)H(29)N(5)O(4), which features a phenyl­ene ring fused with a seven-membered diazepinyl ring. The latter ring adopts a boat conformation (with the methyl­triazolylacetate-bearing C atom as the prow and the fused-ring C atoms as the stern). The benzyl groups connected to the diazepinyl ring jprotrude from the sides; the methyl­triazolylacetate substituent occupies an axial position. International Union of Crystallography 2009-12-12 /pmc/articles/PMC2980270/ /pubmed/21580016 http://dx.doi.org/10.1107/S1600536809052696 Text en © Jabli et al. 2010 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Jabli, Hind
Kandri Rodi, Y.
Ladeira, Sonia
Essassi, El Mokhtar
Ng, Seik Weng
Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate
title Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate
title_full Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate
title_fullStr Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate
title_full_unstemmed Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate
title_short Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1H-1,5-benzo­diazepin-3-yl)meth­yl]-1H-1,2,3-triazol-1-yl}acetate
title_sort ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetra­hydro-1h-1,5-benzo­diazepin-3-yl)meth­yl]-1h-1,2,3-triazol-1-yl}acetate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980270/
https://www.ncbi.nlm.nih.gov/pubmed/21580016
http://dx.doi.org/10.1107/S1600536809052696
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