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The Terneuzen Birth Cohort: BMI Change between 2 and 6 Years Is Most Predictive of Adult Cardiometabolic Risk

BACKGROUND: We recently reported the age interval 2–6y being the earliest and most critical for adult overweight. We now aim to determine which age intervals are predictive of cardiometabolic risk at young adulthood. METHODS AND FINDINGS: We analyzed data from 642 18–28 years olds from the Terneuzen...

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Autores principales: de Kroon, Marlou L. A., Renders, Carry M., van Wouwe, Jacobus P., van Buuren, Stef, Hirasing, Remy A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980469/
https://www.ncbi.nlm.nih.gov/pubmed/21103047
http://dx.doi.org/10.1371/journal.pone.0013966
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author de Kroon, Marlou L. A.
Renders, Carry M.
van Wouwe, Jacobus P.
van Buuren, Stef
Hirasing, Remy A.
author_facet de Kroon, Marlou L. A.
Renders, Carry M.
van Wouwe, Jacobus P.
van Buuren, Stef
Hirasing, Remy A.
author_sort de Kroon, Marlou L. A.
collection PubMed
description BACKGROUND: We recently reported the age interval 2–6y being the earliest and most critical for adult overweight. We now aim to determine which age intervals are predictive of cardiometabolic risk at young adulthood. METHODS AND FINDINGS: We analyzed data from 642 18–28 years olds from the Terneuzen Birth Cohort. Individual BMI SDS trajectories were fitted by a piecewise linear model. By multiple regression analyses relationships were assessed between subsequent conditional BMI SDS changes and components of the metabolic syndrome (MetS), skinfold thickness and hsCRP at young adulthood. Results were adjusted for gender and age, and other confounders. Gender was studied as an effect modifier. All BMI SDS changes throughout childhood were related to waist circumference and skinfold thickness. No other significant relationship was found before the age of 2 years, except between the BMI SDS change 0–1y and hsCRP. Fasting blood glucose was not predicted by any BMI SDS change. BMI SDS change 2–6y was strongly related to most outcome variables, especially to waist circumference (ß 0.47, SE 0.02), systolic and diastolic blood pressure (ß 0.20 SE 0.04 and ß 0.19 SE 0.03), and hsCRP (ß 0.16 SE 0.04). The BMI SDS change 10–18y was most strongly related to HDL cholesterol (ß -0.10, SE 0.03), and triglycerides (ß 0.21, SE 0.03). To a lesser degree, the BMI SDS change 6–10y was related to most outcome variables. BMI SDS changes 2–6y and 10–18y were significantly related to MetS: the OR was respectively 3.39 (95%CI 2.33–4.94) and 2.84 (95%CI 1.94–4.15). CONCLUSION: BMI SDS changes from 2y onwards were related to cardiometabolic risk at young adulthood, the age interval 2–6y being the most predictive. Monitoring and stabilizing the BMI SDS of children as young as 2–6y may not only reverse the progression towards adult overweight, but it may also safeguard cardiometabolic status.
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spelling pubmed-29804692010-11-22 The Terneuzen Birth Cohort: BMI Change between 2 and 6 Years Is Most Predictive of Adult Cardiometabolic Risk de Kroon, Marlou L. A. Renders, Carry M. van Wouwe, Jacobus P. van Buuren, Stef Hirasing, Remy A. PLoS One Research Article BACKGROUND: We recently reported the age interval 2–6y being the earliest and most critical for adult overweight. We now aim to determine which age intervals are predictive of cardiometabolic risk at young adulthood. METHODS AND FINDINGS: We analyzed data from 642 18–28 years olds from the Terneuzen Birth Cohort. Individual BMI SDS trajectories were fitted by a piecewise linear model. By multiple regression analyses relationships were assessed between subsequent conditional BMI SDS changes and components of the metabolic syndrome (MetS), skinfold thickness and hsCRP at young adulthood. Results were adjusted for gender and age, and other confounders. Gender was studied as an effect modifier. All BMI SDS changes throughout childhood were related to waist circumference and skinfold thickness. No other significant relationship was found before the age of 2 years, except between the BMI SDS change 0–1y and hsCRP. Fasting blood glucose was not predicted by any BMI SDS change. BMI SDS change 2–6y was strongly related to most outcome variables, especially to waist circumference (ß 0.47, SE 0.02), systolic and diastolic blood pressure (ß 0.20 SE 0.04 and ß 0.19 SE 0.03), and hsCRP (ß 0.16 SE 0.04). The BMI SDS change 10–18y was most strongly related to HDL cholesterol (ß -0.10, SE 0.03), and triglycerides (ß 0.21, SE 0.03). To a lesser degree, the BMI SDS change 6–10y was related to most outcome variables. BMI SDS changes 2–6y and 10–18y were significantly related to MetS: the OR was respectively 3.39 (95%CI 2.33–4.94) and 2.84 (95%CI 1.94–4.15). CONCLUSION: BMI SDS changes from 2y onwards were related to cardiometabolic risk at young adulthood, the age interval 2–6y being the most predictive. Monitoring and stabilizing the BMI SDS of children as young as 2–6y may not only reverse the progression towards adult overweight, but it may also safeguard cardiometabolic status. Public Library of Science 2010-11-12 /pmc/articles/PMC2980469/ /pubmed/21103047 http://dx.doi.org/10.1371/journal.pone.0013966 Text en de Kroon et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
de Kroon, Marlou L. A.
Renders, Carry M.
van Wouwe, Jacobus P.
van Buuren, Stef
Hirasing, Remy A.
The Terneuzen Birth Cohort: BMI Change between 2 and 6 Years Is Most Predictive of Adult Cardiometabolic Risk
title The Terneuzen Birth Cohort: BMI Change between 2 and 6 Years Is Most Predictive of Adult Cardiometabolic Risk
title_full The Terneuzen Birth Cohort: BMI Change between 2 and 6 Years Is Most Predictive of Adult Cardiometabolic Risk
title_fullStr The Terneuzen Birth Cohort: BMI Change between 2 and 6 Years Is Most Predictive of Adult Cardiometabolic Risk
title_full_unstemmed The Terneuzen Birth Cohort: BMI Change between 2 and 6 Years Is Most Predictive of Adult Cardiometabolic Risk
title_short The Terneuzen Birth Cohort: BMI Change between 2 and 6 Years Is Most Predictive of Adult Cardiometabolic Risk
title_sort terneuzen birth cohort: bmi change between 2 and 6 years is most predictive of adult cardiometabolic risk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980469/
https://www.ncbi.nlm.nih.gov/pubmed/21103047
http://dx.doi.org/10.1371/journal.pone.0013966
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