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Sox2 Is Essential for Formation of Trophectoderm in the Preimplantation Embryo
BACKGROUND: In preimplantation mammalian development the transcription factor Sox2 (SRY-related HMG-box gene 2) forms a complex with Oct4 and functions in maintenance of self-renewal of the pluripotent inner cell mass (ICM). Previously it was shown that Sox2−/− embryos die soon after implantation. H...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980489/ https://www.ncbi.nlm.nih.gov/pubmed/21103067 http://dx.doi.org/10.1371/journal.pone.0013952 |