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Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins. In general, however, live animal drug screening is labor and resou...

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Detalles Bibliográficos
Autores principales:	Gosai, Sager J., Kwak, Joon Hyeok, Luke, Cliff J., Long, Olivia S., King, Dale E., Kovatch, Kevin J., Johnston, Paul A., Shun, Tong Ying, Lazo, John S., Perlmutter, David H., Silverman, Gary A., Pak, Stephen C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2980495/ https://www.ncbi.nlm.nih.gov/pubmed/21103396 http://dx.doi.org/10.1371/journal.pone.0015460

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