Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets

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Recognition of pancreatic beta cell antigens by autoreactive T lymphocytes plays a central role in the pathogenesis of insulin-dependent type 1 diabetes. Recent results suggest that non-conventional antigenic epitope processing and presentation may contribute to triggering and maintaining autoreacti...

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Detalles Bibliográficos
Autores principales: Moser, Anna, Hsu, Hsiang-Ting, van Endert, Peter
Formato: Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981181/
https://www.ncbi.nlm.nih.gov/pubmed/21173836
http://dx.doi.org/10.3410/B2-75
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author Moser, Anna
Hsu, Hsiang-Ting
van Endert, Peter
author_facet Moser, Anna
Hsu, Hsiang-Ting
van Endert, Peter
author_sort Moser, Anna
collection PubMed
description Recognition of pancreatic beta cell antigens by autoreactive T lymphocytes plays a central role in the pathogenesis of insulin-dependent type 1 diabetes. Recent results suggest that non-conventional antigenic epitope processing and presentation may contribute to triggering and maintaining autoreactive responses. Moreover, promising results raise hope that autoantigens may become safe and specific therapeutics for type 1 diabetes in the future.
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spelling pubmed-29811812010-12-20 Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets Moser, Anna Hsu, Hsiang-Ting van Endert, Peter F1000 Biol Rep Review Article Recognition of pancreatic beta cell antigens by autoreactive T lymphocytes plays a central role in the pathogenesis of insulin-dependent type 1 diabetes. Recent results suggest that non-conventional antigenic epitope processing and presentation may contribute to triggering and maintaining autoreactive responses. Moreover, promising results raise hope that autoantigens may become safe and specific therapeutics for type 1 diabetes in the future. Faculty of 1000 Ltd 2010-10-21 /pmc/articles/PMC2981181/ /pubmed/21173836 http://dx.doi.org/10.3410/B2-75 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Moser, Anna
Hsu, Hsiang-Ting
van Endert, Peter
Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets
title Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets
title_full Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets
title_fullStr Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets
title_full_unstemmed Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets
title_short Beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets
title_sort beta cell antigens in type 1 diabetes: triggers in pathogenesis and therapeutic targets
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981181/
https://www.ncbi.nlm.nih.gov/pubmed/21173836
http://dx.doi.org/10.3410/B2-75
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AT vanendertpeter betacellantigensintype1diabetestriggersinpathogenesisandtherapeutictargets

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