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BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study

BACKGROUND: The optimal range of relative weight for morbidity and mortality in Asian populations is an important question in need of more thorough investigation, especially as obesity rates increase. We aimed to examine the association between body mass index (BMI), all cause and cause-specific mor...

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Autores principales: Odegaard, Andrew O., Pereira, Mark A., Koh, Woon-Puay, Gross, Myron D., Duval, Sue, Yu, Mimi C., Yuan, Jian-Min
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981556/
https://www.ncbi.nlm.nih.gov/pubmed/21085577
http://dx.doi.org/10.1371/journal.pone.0014000
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author Odegaard, Andrew O.
Pereira, Mark A.
Koh, Woon-Puay
Gross, Myron D.
Duval, Sue
Yu, Mimi C.
Yuan, Jian-Min
author_facet Odegaard, Andrew O.
Pereira, Mark A.
Koh, Woon-Puay
Gross, Myron D.
Duval, Sue
Yu, Mimi C.
Yuan, Jian-Min
author_sort Odegaard, Andrew O.
collection PubMed
description BACKGROUND: The optimal range of relative weight for morbidity and mortality in Asian populations is an important question in need of more thorough investigation, especially as obesity rates increase. We aimed to examine the association between body mass index (BMI), all cause and cause-specific mortality to determine the optimal range of BMI in relation to mortality in Chinese men and women in Singapore. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed data from a prospective cohort study of 51,251 middle-aged or older (45–74) Chinese men and women in the Singapore Chinese Health Study. Participants were enrolled and data on body weight and covariates were collected in 1993–1998 and participants were followed through 2008. The analysis accounted for potential methodological issues through stratification on smoking and age, thorough adjustment of demographic and lifestyle confounders and exclusion of deaths early in the follow-up. CONCLUSIONS/SIGNIFICANCE: Increased risk of mortality was apparent in underweight (<18.5) and obese BMI categories (≥27.5) independent of age and smoking. Regardless of age or BMI, smoking considerably increased the rate of mortality and modified the association between BMI and mortality. The most favorable range of BMI for mortality rates and risk in non-smoking persons below age 65 was 18.5–21.4 kg/m(2), and for non-smoking persons aged 65 and above was 21.5–24.4 kg/m(2).
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spelling pubmed-29815562010-11-17 BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study Odegaard, Andrew O. Pereira, Mark A. Koh, Woon-Puay Gross, Myron D. Duval, Sue Yu, Mimi C. Yuan, Jian-Min PLoS One Research Article BACKGROUND: The optimal range of relative weight for morbidity and mortality in Asian populations is an important question in need of more thorough investigation, especially as obesity rates increase. We aimed to examine the association between body mass index (BMI), all cause and cause-specific mortality to determine the optimal range of BMI in relation to mortality in Chinese men and women in Singapore. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed data from a prospective cohort study of 51,251 middle-aged or older (45–74) Chinese men and women in the Singapore Chinese Health Study. Participants were enrolled and data on body weight and covariates were collected in 1993–1998 and participants were followed through 2008. The analysis accounted for potential methodological issues through stratification on smoking and age, thorough adjustment of demographic and lifestyle confounders and exclusion of deaths early in the follow-up. CONCLUSIONS/SIGNIFICANCE: Increased risk of mortality was apparent in underweight (<18.5) and obese BMI categories (≥27.5) independent of age and smoking. Regardless of age or BMI, smoking considerably increased the rate of mortality and modified the association between BMI and mortality. The most favorable range of BMI for mortality rates and risk in non-smoking persons below age 65 was 18.5–21.4 kg/m(2), and for non-smoking persons aged 65 and above was 21.5–24.4 kg/m(2). Public Library of Science 2010-11-15 /pmc/articles/PMC2981556/ /pubmed/21085577 http://dx.doi.org/10.1371/journal.pone.0014000 Text en Odegaard et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Odegaard, Andrew O.
Pereira, Mark A.
Koh, Woon-Puay
Gross, Myron D.
Duval, Sue
Yu, Mimi C.
Yuan, Jian-Min
BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study
title BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study
title_full BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study
title_fullStr BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study
title_full_unstemmed BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study
title_short BMI, All-Cause and Cause-Specific Mortality in Chinese Singaporean Men and Women: The Singapore Chinese Health Study
title_sort bmi, all-cause and cause-specific mortality in chinese singaporean men and women: the singapore chinese health study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981556/
https://www.ncbi.nlm.nih.gov/pubmed/21085577
http://dx.doi.org/10.1371/journal.pone.0014000
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