A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl(2) ha...

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Detalles Bibliográficos
Autores principales: Moirangthem, Nimalini Devi, Laitonjam, Warjeet Singh
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2010
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981811/
https://www.ncbi.nlm.nih.gov/pubmed/21085498
http://dx.doi.org/10.3762/bjoc.6.120
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author Moirangthem, Nimalini Devi
Laitonjam, Warjeet Singh
author_facet Moirangthem, Nimalini Devi
Laitonjam, Warjeet Singh
author_sort Moirangthem, Nimalini Devi
collection PubMed
description A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl(2) has been developed.
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spelling pubmed-29818112010-11-17 A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative Moirangthem, Nimalini Devi Laitonjam, Warjeet Singh Beilstein J Org Chem Full Research Paper A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl(2) has been developed. Beilstein-Institut 2010-11-09 /pmc/articles/PMC2981811/ /pubmed/21085498 http://dx.doi.org/10.3762/bjoc.6.120 Text en Copyright © 2010, Moirangthem and Laitonjam https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Moirangthem, Nimalini Devi
Laitonjam, Warjeet Singh
A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative
title A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative
title_full A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative
title_fullStr A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative
title_full_unstemmed A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative
title_short A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative
title_sort new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981811/
https://www.ncbi.nlm.nih.gov/pubmed/21085498
http://dx.doi.org/10.3762/bjoc.6.120
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