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Outcome measurements in orthopedic

The choice of outcome measure in orthopedic clinical research studies is paramount. The primary outcome measure for a study has several implications for the design and conduct of the study. These include: 1) sample size determination, 2) internal validity, 3) compliance and 4) cost. A thorough knowl...

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Detalles Bibliográficos
Autores principales: Bhandari, Mohit, Petrisor, Brad, Schemitsch, Emil
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981892/
https://www.ncbi.nlm.nih.gov/pubmed/21124680
http://dx.doi.org/10.4103/0019-5413.30523
Descripción
Sumario:The choice of outcome measure in orthopedic clinical research studies is paramount. The primary outcome measure for a study has several implications for the design and conduct of the study. These include: 1) sample size determination, 2) internal validity, 3) compliance and 4) cost. A thorough knowledge of outcome measures in orthopedic research is paramount to the conduct of a quality study. The decision to choose a continuous versus dichotomous outcome has important implications for sample size. However, regardless of the type of outcome, investigators should always use the most ‘patient-important’ outcome and limit bias in its determination.