AN IMMUNOMODULATOR IN THE TREATMENT OF SCHIZOPHRENIA : A DOUBLE-BLIND STUDY

In a double blind study, the immunomodulator drug levamisole was administered along with chloropromazine to 18 schizophrenic patients, and efficiency of the combination was compared to that of chloropromazine along with placebo administered to 16 schizophrenic patients. The decrease in T suppressor...

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Detalles Bibliográficos
Autores principales: Agarwal, S., Agarwal, A.K., Tewari, S.C., Dalal, P.K., Bahuguna, L.M.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 1992
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982081/
https://www.ncbi.nlm.nih.gov/pubmed/21776131
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author Agarwal, S.
Agarwal, A.K.
Tewari, S.C.
Dalal, P.K.
Bahuguna, L.M.
author_facet Agarwal, S.
Agarwal, A.K.
Tewari, S.C.
Dalal, P.K.
Bahuguna, L.M.
author_sort Agarwal, S.
collection PubMed
description In a double blind study, the immunomodulator drug levamisole was administered along with chloropromazine to 18 schizophrenic patients, and efficiency of the combination was compared to that of chloropromazine along with placebo administered to 16 schizophrenic patients. The decrease in T suppressor cell count found in both groups at benchmark was found to be corrected in the patients receiving levamisole and this increase in T suppressor cell count was significantly correlated with the improvement in psychosis. The findings provide evidence in favour of the autoimmune hypothesis of schizophrenia.
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spelling pubmed-29820812011-07-20 AN IMMUNOMODULATOR IN THE TREATMENT OF SCHIZOPHRENIA : A DOUBLE-BLIND STUDY Agarwal, S. Agarwal, A.K. Tewari, S.C. Dalal, P.K. Bahuguna, L.M. Indian J Psychiatry Original Article In a double blind study, the immunomodulator drug levamisole was administered along with chloropromazine to 18 schizophrenic patients, and efficiency of the combination was compared to that of chloropromazine along with placebo administered to 16 schizophrenic patients. The decrease in T suppressor cell count found in both groups at benchmark was found to be corrected in the patients receiving levamisole and this increase in T suppressor cell count was significantly correlated with the improvement in psychosis. The findings provide evidence in favour of the autoimmune hypothesis of schizophrenia. Medknow Publications 1992 /pmc/articles/PMC2982081/ /pubmed/21776131 Text en Copyright: © Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Agarwal, S.
Agarwal, A.K.
Tewari, S.C.
Dalal, P.K.
Bahuguna, L.M.
AN IMMUNOMODULATOR IN THE TREATMENT OF SCHIZOPHRENIA : A DOUBLE-BLIND STUDY
title AN IMMUNOMODULATOR IN THE TREATMENT OF SCHIZOPHRENIA : A DOUBLE-BLIND STUDY
title_full AN IMMUNOMODULATOR IN THE TREATMENT OF SCHIZOPHRENIA : A DOUBLE-BLIND STUDY
title_fullStr AN IMMUNOMODULATOR IN THE TREATMENT OF SCHIZOPHRENIA : A DOUBLE-BLIND STUDY
title_full_unstemmed AN IMMUNOMODULATOR IN THE TREATMENT OF SCHIZOPHRENIA : A DOUBLE-BLIND STUDY
title_short AN IMMUNOMODULATOR IN THE TREATMENT OF SCHIZOPHRENIA : A DOUBLE-BLIND STUDY
title_sort immunomodulator in the treatment of schizophrenia : a double-blind study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982081/
https://www.ncbi.nlm.nih.gov/pubmed/21776131
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