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Change of the aortic elasticity in rheumatoid arthritis: Relationship to associated cardiovascular risk factors

INTRODUCTION: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease, which is associated with an excess of cardiovascular events. A decrease in the compliance of the arterial system, termed arterial stiffness, results in increased cardiac workload. Primary prevention of cardiovascul...

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Autores principales: Sliem, Hamdy, Nasr, Gamela
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982197/
https://www.ncbi.nlm.nih.gov/pubmed/21187863
http://dx.doi.org/10.4103/0975-3583.70901
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author Sliem, Hamdy
Nasr, Gamela
author_facet Sliem, Hamdy
Nasr, Gamela
author_sort Sliem, Hamdy
collection PubMed
description INTRODUCTION: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease, which is associated with an excess of cardiovascular events. A decrease in the compliance of the arterial system, termed arterial stiffness, results in increased cardiac workload. Primary prevention of cardiovascular disease (CVD) is a priority for modern medicine. Therefore, further studies are required to explore the mechanisms through which CVD increases in RA. PATIENTS AND METHODS: This case–control study was performed to detect possible change of aortic elasticity in patients with RA, and to estimate the impact of different cardiovascular and atherogenic risk factors on the severity of arterial stiffness. Sixty-three consecutive adults with RA were enrolled for the study (case group). Forty-one healthy adults matched for age and gender were considered as a control group. All were subjected to assessment of aortic stiffness index and various cardiovascular risk factors. Patients with rheumatoid disease (case group) were divided by their aortic stiffness index status to two groups (A and B, with and without aortic stiffness, respectively). RESULTS: Aortic stiffness was present in 31.7% of the RA patients. Age of the patients, duration of RA, smoking index, waist circumference, triglycerides levels, and CRP were significantly higher in patients with aortic stiffness. CONCLUSION: RA is associated with decreased elasticity of the aorta in both genders, and such changes seem to be higher in the presence of visceral obesity, smoking, high triglycerides, and extraarticular disease severity.
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spelling pubmed-29821972010-12-23 Change of the aortic elasticity in rheumatoid arthritis: Relationship to associated cardiovascular risk factors Sliem, Hamdy Nasr, Gamela J Cardiovasc Dis Res Original Paper INTRODUCTION: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease, which is associated with an excess of cardiovascular events. A decrease in the compliance of the arterial system, termed arterial stiffness, results in increased cardiac workload. Primary prevention of cardiovascular disease (CVD) is a priority for modern medicine. Therefore, further studies are required to explore the mechanisms through which CVD increases in RA. PATIENTS AND METHODS: This case–control study was performed to detect possible change of aortic elasticity in patients with RA, and to estimate the impact of different cardiovascular and atherogenic risk factors on the severity of arterial stiffness. Sixty-three consecutive adults with RA were enrolled for the study (case group). Forty-one healthy adults matched for age and gender were considered as a control group. All were subjected to assessment of aortic stiffness index and various cardiovascular risk factors. Patients with rheumatoid disease (case group) were divided by their aortic stiffness index status to two groups (A and B, with and without aortic stiffness, respectively). RESULTS: Aortic stiffness was present in 31.7% of the RA patients. Age of the patients, duration of RA, smoking index, waist circumference, triglycerides levels, and CRP were significantly higher in patients with aortic stiffness. CONCLUSION: RA is associated with decreased elasticity of the aorta in both genders, and such changes seem to be higher in the presence of visceral obesity, smoking, high triglycerides, and extraarticular disease severity. Medknow Publications 2010 /pmc/articles/PMC2982197/ /pubmed/21187863 http://dx.doi.org/10.4103/0975-3583.70901 Text en © Journal of Cardiovascular Disease Research http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Sliem, Hamdy
Nasr, Gamela
Change of the aortic elasticity in rheumatoid arthritis: Relationship to associated cardiovascular risk factors
title Change of the aortic elasticity in rheumatoid arthritis: Relationship to associated cardiovascular risk factors
title_full Change of the aortic elasticity in rheumatoid arthritis: Relationship to associated cardiovascular risk factors
title_fullStr Change of the aortic elasticity in rheumatoid arthritis: Relationship to associated cardiovascular risk factors
title_full_unstemmed Change of the aortic elasticity in rheumatoid arthritis: Relationship to associated cardiovascular risk factors
title_short Change of the aortic elasticity in rheumatoid arthritis: Relationship to associated cardiovascular risk factors
title_sort change of the aortic elasticity in rheumatoid arthritis: relationship to associated cardiovascular risk factors
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982197/
https://www.ncbi.nlm.nih.gov/pubmed/21187863
http://dx.doi.org/10.4103/0975-3583.70901
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