High density lipoproteins-based therapies for cardiovascular disease

Atherosclerosis is the leading cause of death in developed countries. High density lipoproteins (HDL) cholesterol level correlates inversely with the risk of cardiovascular diseases. Thus, HDL has obtained lots of interest for drug development. In this review, we summarized the mechanisms for the an...

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Detalles Bibliográficos
Autores principales: Gao, Xuan, Yuan, Shujun
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982209/
https://www.ncbi.nlm.nih.gov/pubmed/21187875
http://dx.doi.org/10.4103/0975-3583.70898
Descripción
Sumario:Atherosclerosis is the leading cause of death in developed countries. High density lipoproteins (HDL) cholesterol level correlates inversely with the risk of cardiovascular diseases. Thus, HDL has obtained lots of interest for drug development. In this review, we summarized the mechanisms for the antiatherogenic function of HDL, current HDL-based drugs in clinical use and the future direction for HDL-based therapy development.

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